益生菌治疗神经源性肠道功能障碍(便秘型)的效果研究  

Study on the Effect of Probiotics in the Treatment of Neurogenic Bowel Dysfunction(Constipation Type)

作　　者：柯柳娴 曹玲娟 李尚 KE Liuxian;CAO Lingjuan;LI Shang(Department of Pharmacy,Guangdong Work Injury Rehabilitation Hospital,Guangzhou 510000,Guangdong,China)

机构地区：[1]广东省工伤康复医院药剂科,广东广州510000

出　　处：《中外医疗》2024年第17期100-103,共4页China & Foreign Medical Treatment

摘　　要：目的 分析益生菌在治疗神经源性肠道功能障碍(便秘型)的获益情况。方法 回顾性选取广东省工伤康复医院于2020—2021年收治的159例神经源性肠功能障碍(便秘型)住院患者的临床资料,根据治疗方法的不同进行分组,对照组(n=116例,行乳果糖、甲氧氯普胺治疗)和观察组(n=43例,加用益生菌治疗),比较两组患者的排便情况。结果 治疗后,观察组的排便频率为(3.56±0.53)次/周,优于对照组的(2.86±0.41)次/周;排便时间为(9.41±1.14)min,短于对照组的(10.32±1.66)min,差异有统计学意义(t=7.830、3.922,P均<0.05)。治疗后,观察组胃肠激素水平优于对照组,差异有统计学意义(P<0.05)。观察组治疗2周、1个月后神经源性肠功能障碍评分低于对照组,差异有统计学意义(P均<0.05)。结论 针对神经源性肠功能障碍(便秘型)患者,加用益生菌可以增加排便频率,改善胃肠激素水平以及神经源性肠功能障碍评分。Objective To analyze the benefits of probiotics in the treatment of neurogenic bowel dysfunction(constipation type).Methods The clinical data of 159 hospitalized patients with neurogenic bowel dysfunction(constipation type) admitted to the Guangdong Work Injury Rehabilitation Hospital from 2020 to 2021 were retrospectively selected.They were grouped according to the different treatment methods,the control group(n=116 cases,treated with lactulose and metoclopramide) and the observation group(n=43 cases,treated with probiotics),and the defecation of the patients in the two groups was compared.Results After treatment,the frequency of defecation in the observation group was(3.56±0.53) times/week,which was better than that in the control group(2.86±0.41) times/week;the time of defecation was(9.41±1.14) min,which was shorter than that in the control group(10.32±1.66) min,and the differences were statistically significant(t=7.830,3.922,both P<0.05).After treatment,the gastrointestinal hormone level of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The scores of neurogenic bowel dysfunction in the observation group were lower than those in the control group after 2weeks and 1 month of treatment,and the differences were statistically significant(both P<0.05).Conclusion For patients with neurogenic bowel alysfunction,the addition of probiotics can increase the frequency of defecation and improve gastrointestinal hormone levels as well as neurogenic bowel dysfunction scores.

关 键 词：益生菌 神经源性肠道功能障碍 便秘 

分 类 号：R547[医药卫生—心血管疾病]