芍麻止痉颗粒联合耳穴压豆对小儿抽动障碍症状改善及微量元素水平的影响  

Effect of Shaoma Zhijing Granules Combined with Ear Point Pressing Beans on the Symptom Improvement and Trace Element Levels in Children with Tic Disorder

作　　者：古欣 岑丽婷 李嫦红 GU Xin;CEN Liting;LI Changhong(Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong,China 510006;The First People′s Hospital of Zhaoqing City,Zhaoqing,Guangdong,China 510405)

机构地区：[1]广州中医药大学,广东广州510006 [2]广东省肇庆市第一人民医院,广东肇庆510405

出　　处：《中国药业》2024年第15期81-84,共4页China Pharmaceuticals

基　　金：广东省中医药局科研项目[20222290]。

摘　　要：目的 探讨芍麻止痉颗粒联合耳穴压豆对小儿抽动障碍症状改善及微量元素水平的影响。方法 选取广东省肇庆市第一人民医院2022年1月至2023年3月收治的小儿抽动障碍患儿80例,按随机数字表法分为观察组和对照组,各40例。两组患儿均口服盐酸硫必利片,观察组患儿加用芍麻止痉颗粒联合耳穴压豆,均连续治疗8周。结果 观察组总有效率为95.00%,显著高于对照组的65.00%(P <0.05)。治疗后,观察组患儿的耶鲁综合抽动严重程度量表(YGTSS)评分、各项中医证候积分、铅、去甲肾上腺素和多巴胺水平均显著低于对照组(P <0.05),但脑源性神经营养因子水平及锌、铁均显著高于对照组(P <0.05)。结论 芍麻止痉颗粒联合耳穴压豆治疗小儿抽动障碍的临床疗效较好,可改善患儿的临床症状,调节神经递质及微量元素水平。Objective To investigate the effect of Shaoma Zhijing Granules combined with ear point pressing beans on symptom improvement and trace element levels in children with tic disorder.Methods A total of 80 children with tic disorder admitted to The First People′s Hospital of Zhaoqing City from January 2022 to March 2023 were selected and randomly divided into the observation group and the control group,with 40 cases in each group.The children in the two groups received oral administration of Thipride Hydrochloride Tablets,on this basis,the children in the observation group were treated with Shaoma Zhijing Granules combined with ear acupoint pressing beans.Both groups were treated continuously for eight weeks.Results The total effective rate in the observation group was 95.00%,which was significantly higher than 65.00% in the control group(P < 0.05).After treatment,the Yale Global Tic Severity Scale(YGTSS) score,each traditional Chinese medicine syndrome score,the levels of lead(Pb),norepinephrine(NE),and dopamine(DA) in the observation group were significantly lower than those in the control group(P < 0.05),while the levels of brain-derived neurotrophic factor(BDNF),zinc(Zn),and iron(Fe) in the observation group were significantly higher than those in the control group(P < 0.05).Conclusion Shaoma Zhijing Granules combined with ear acupoint pressing beans has good clinical efficacy in the treatment of children with tic disorders,which can improve clinical symptoms,and regulate neurotransmitter and trace element levels.

关 键 词：芍麻止痉颗粒 耳穴压豆 小儿抽动障碍 中医证候 微量元素 神经递质 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]