重组人生长激素联合醋酸亮丙瑞林对中枢性性早熟女童的影响  

The Effect of Recombinant Human Growth Hormone Combined with Leuprorelin Acetate on Central Precocious Puberty Girls

作　　者：唐海霞 TANG Haixia(Department of Pediatrics,The 83rd Group Army Hospital of PLA,Xinxiang Henan 453000,China)

机构地区：[1]中国人民解放军陆军第八十三集团军医院儿科,河南新乡453000

出　　处：《临床研究》2024年第8期72-75,共4页Clinical Research

摘　　要：目的探究重组人生长激素联合醋酸亮丙瑞林对中枢性性早熟女童性征异常和骨代谢的临床作用效果。方法选择2021年2月至2023年10月间中国人民解放军陆军第八十三集团军医院收治的89例中枢性早熟女童进行研究并随机分为对照组和观察组。对照组44例患儿给予醋酸亮丙瑞林治疗,观察组45例患儿给予重组人生长激素联合醋酸亮丙瑞林治疗。治疗6个月后评估两组患儿的临床疗效及治疗期间安全性,对比两组患儿治疗前后性激素水平、第二性征表现、生长发育情况及骨代谢指标变化。结果治疗后,观察组患儿治疗有效率均显著优于对照组,差异有统计学意义(P<0.05)。治疗前两组患儿性激素、第二性征以及骨代谢指标的检测结果对比差异无统计学意义(P>0.05);治疗后,两组患儿促黄体生成激素(LH)、促卵泡成熟激素(FSH)、雌二醇(E_(2))表达水平、第二性征各指标(乳腺体积、子宫体积、卵巢平均容积、卵泡最大直径)检测结果以及骨代谢指标[血清骨钙(OST)、骨钙素N端中分子片段(N-MID)、Ⅰ型前胶原氨基端肽(PINP)]结果均明显降低,其中观察组显著低于对照组,差异有统计学意义(P<0.05)。观察组患儿治疗前后身高差、预估成年身高明显高于对照组,差异有统计学意义(P<0.05),两组患儿的骨龄对比差异无统计学意义(P>0.05)。治疗期间两组患儿的不良反应发生率对比差异无统计学意义(P>0.05)。结论给予中枢性性早熟女童重组人生长激素联合醋酸亮丙瑞林治疗可以有效改善患儿的病症,抑制第二性征的异常发展并纠正骨代谢水平,应用效果较理想。Objective To explore the clinical effect of recombinant human growth hormone combined with leuprorelin acetate on sexual development abnormalities and bone metabolism in girls with central precocious puberty.Methods From February 2021 to October 2023,89 girls with central precocious puberty treated in the 83rd Group Army Hospital of PLA were selected for the study and randomly divided into a control group and an observation group.The control group of 44 children was treated with leuprorelin acetate,and the observation group of 45 children was treated with recombinant human growth hormone combined with leuprorelin acetate.After 6 months of treatment,the clinical efficacy and safety during treatment of the two groups of children were evaluated,and the changes in sex hormone levels,secondary sexual characteristics,growth and development,and bone metabolism indicators before and after treatment were compared.Results After treatment,the effective rate of treatment in the observation group was significantly better than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistical significance in the comparison of sex hormones,secondary sexual characteristics,and bone metabolism indicators between the two groups(P>0.05);after treatment,the levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E_(2)),various indicators of secondary sexual characteristics(breast volume,uterine volume,average ovarian volume,maximum follicle diameter),and bone metabolism indicators[serum osteocalcin(OST),N-terminal mid-fragment(N-MID),TypeⅠprocollagen N-terminal peptide(PINP)]in both groups were significantly reduced,among which the observation group was significantly lower than the control group,and the difference was statistically significant(P<0.05).The height difference before and after treatment and the estimated adult height of the children in the observation group were significantly higher than those in the control group,and the difference was st

关 键 词：中枢性性早熟 儿科 重组人生长激素 醋酸亮丙瑞林 性征异常 骨代谢 

分 类 号：R585[医药卫生—内分泌]