米非司酮连续给药与改良短周期疗法治疗围绝经期功能障碍性子宫出血的效果  

Effect of Continuous Administration of Mifepristone and Modified Short-Cycle Therapy on Perimenopausal Dysfunctional Uterine Bleeding

作　　者：郑冬梅 孙超佳 ZHENG Dongmei;SUN Chaojia(Department of Obstetrics and Gynecology,Donghedian Town Central Health Center,Pingyu Henan 463400,China;Department of Obstetrics and Gynecology,Zhumadian Central Hospital,Zhumadian Henan 463000,China)

机构地区：[1]平舆县东和店镇中心卫生院妇产科,河南平舆463400 [2]驻马店市中心医院妇产科,河南驻马店463000

出　　处：《临床研究》2024年第8期79-81,共3页Clinical Research

摘　　要：目的探索米非司酮连续给药与改良短周期疗法对围绝经期功能障碍性子宫出血患者的效果。方法将平舆县东和店镇中心卫生院2021年8月至2023年8月收治的76例围绝经期功能障碍性子宫出血患者以系统随机化法均分为两组,各38例。两组均采用米非司酮治疗,其中对照组为连续给药,观察组则运用改良短周期疗法。比较两组的子宫超声指标水平、性激素水平、不良反应发生情况、复发情况与闭经发生情况。结果治疗前两组子宫体积及子宫内膜厚度比较,差异无统计学意义(P>0.05)。治疗后,两组子宫体积及子宫内膜厚度较治疗前均缩小,观察组较对照组缩小更明显,差异具有统计学意义(P<0.05)。治疗后,观察组雌二醇、孕酮、卵泡刺激素水平均低于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率(2.63%)低于对照组(18.42%),差异存在统计学意义(P<0.05)。由随访情况可得观察组复发率与闭经发生率低于对照组,组间差异有统计学意义(P<0.05)。结论运用米非司酮短周期疗法相较于米非司酮连续给药疗法,可有效保障患者的子宫健康,缓解子宫出血情况,有效降低复发率与闭经发生率。Objective To explore the effects of continuous administration of mifepristone and modified short-cycle therapy on patients with perimenopausal dysfunctional uterine bleeding.Methods Seventy-six patients with perimenopausal dysfunctional uterine bleeding treated at Donghedian Town Central Health Center,Pingyu County,from August 2021 to August 2023 were randomly divided into two groups,with 38 cases in each group.Both groups were treated with mifepristone,with the control group receiving continuous administration and the observation group receiving modified short-cycle therapy.The uterine ultrasound indicators,sex hormone levels,incidence of adverse reactions,recurrence,and occurrence of amenorrhea were compared between the two groups.Results Before treatment,there were no statistically significant differences in uterine volume and endometrial thickness between the two groups(P>0.05).After treatment,both uterine volume and endometrial thickness were reduced in both groups,with the observation group showing a more significant reduction compared to the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of estradiol,progesterone,and folliclestimulating hormone in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the observation group(2.63%)was lower than that in the control group(18.42%),with statistically significant differences(P<0.05).Follow-up results showed that the recurrence rate and incidence of amenorrhea in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Compared to continuous administration of mifepristone,the modified short-cycle therapy can effectively ensure uterine health,alleviate uterine bleeding,and significantly reduce the recurrence rate and incidence of amenorrhea.

关 键 词：米非司酮 功能障碍性出血 子宫内膜厚度 

分 类 号：R711.52[医药卫生—妇产科学]