第四代喹诺酮类抗菌药盐酸莫西沙星合成工艺进展与优化  

Synthesis Process Progress and Optimization of Moxifloxacin Hydrochloride Which is the Fourth Generation of Quinolone Antibacterial Drug

作　　者：杨子琪 YANG Ziqi

机构地区：[1]杨凌职业技术学院,陕西杨凌712100

出　　处：《化工设计通讯》2024年第7期166-169,共4页Chemical Engineering Design Communications

基　　金：杨凌职业技术学院院内基金项目(ZK20-75)。

摘　　要：盐酸莫西沙星是第四代氟喹诺酮类药物,临床应用领域广、效果良好,市场需求巨大,因此,研究盐酸莫西沙星合成工艺实现降本增产,对于制药行业和患者双方都有着很强的现实意义。通过对近年来盐酸莫西沙星合成工艺的进展与优化情况进行综述,探讨几种主要方法的优劣,并尝试汇总出一条较为可行、具有探索实验意义的工艺路线。Moxifl oxacin hydrochloride is a fourth-generation fl uoroquinolone drug with a wide range of clinical applications,good efficacy,so as a huge market demand.Therefore,study in the synthesis process of moxifloxacin hydrochloride to achieve cost reduction and production increase has strong practical significance for both the pharmaceutical industry and patients.this article reviews the progress and optimization of the synthesis process of moxifloxacin hydrochloride in recent years,discusses the advantages and disadvantages of several main methods,and attempts to summarize a feasible and exploratory experimental process route.

关 键 词：盐酸莫西沙星 盐酸莫西沙星侧链 (S S)-2 8-二氮杂双环[4.3.0]壬烷 喹啉羧酸 盐酸莫西沙星合成路线 

分 类 号：R95[医药卫生—药学]