深化对血乳酸在脓毒症中作用与意义的新认识  

New insight of the important role and the significance of lactate in sepsis

作　　者：刘辉 祝筱梅[2] 姚咏明[2] Liu Hui;Zhu Xiaomei;Yao Yongming(Critical Care Medicine Department,the First Medical Center,the Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第一医学中心重症医学科,北京100853 [2]中国人民解放军总医院医学创新研究部,北京100853

出　　处：《中国急救医学》2024年第8期668-671,共4页Chinese Journal of Critical Care Medicine

基　　金：国家自然科学基金重点项目(82241062,82130062);北京市自然科学基金项目(7222162)。

摘　　要：作为反映组织低灌注的重要指标,早期血乳酸水平及其变化趋势与脓毒症患者预后关系密切。新近研究证实,乳酸可参与机体天然和获得性免疫调控,并且具有转录后修饰功能,直接影响脓毒症发展。非缺氧型乳酸增多、有氧糖酵解、主要能量底物等重要科学问题不断赋予乳酸新的角色和功能,很有必要深刻认识乳酸的作用与意义。As the key biomarker of tissue hypoperfusion,early lactate level and its clearance rate are related closely to the prognosis of sepsis.Recent studies have been demonstrated that lactate appears to be a crucial signal involving in both innate and adaptive immune responses.Lactate is able to induce protein lactylation,which is proved to regulate the function of cytokines through post-translational modification.Newly hot topics are increasing attention to the lactate production and regulation,including non-anoxic increment of lactate,aerobic glycolysis,and important energy substrate.It is necessary to update our knowledge concerning lactate in sepsis.

关 键 词：血乳酸 脓毒症 转录后修饰 有氧糖酵解 免疫调控 

分 类 号：R459.7[医药卫生—急诊医学]