藏茵陈有效成分改善代谢综合征的作用机制研究进展  

Research progress on the improvement mechanism of active ingredients of Swertia mussotii on metabolic syndrome

作　　者：吴涛 刘立[1] 宋红萍[1] WUTao;LIULi;SONGHongping(Dept.of Pharmacy,Wuhan Fourth Hospital,Wuhan 430033,China)

机构地区：[1]武汉市第四医院药学部,武汉430033

出　　处：《中国药房》2024年第15期1928-1932,共5页China Pharmacy

基　　金：武汉市科技局知识创新专项(No.2023020201010195)。

摘　　要：代谢综合征(MS)是以肥胖、糖脂代谢异常以及高血压为主要特征的临床症候群。藏茵陈是我国藏族民间常用药,其功效与MS病机吻合,对MS具有对症治疗潜力。本文对藏茵陈有效成分改善MS的作用机制进行总结发现,龙胆苦苷、獐牙菜苷、獐牙菜苦苷、芒果苷、齐墩果酸等有效成分可通过调节糖脂代谢、改善肥胖、调节心血管系统、抗慢性炎症、抗氧化应激、抗内质网应激、调节自噬、调节肠道菌群紊乱,发挥改善MS的作用。Metabolic syndrome(MS)is a complex group of clinical syndromes with obesity,abnormal glucose and lipid metabolism and hypertension as the main clinical features.Swertia mussotii is a commonly used medicine among the Tibetan people in China.Its efficacy is consistent with the pathogenesis of MS,which has the potential for symptomatic treatment of MS.It is found that effective ingredients such as gentiopicroside,sweroside,swertiamarin,mangiferin,and oleanolic acid can improve MS by regulating glucose and lipid metabolism,improving obesity,regulating the cardiovascular system,inhibiting chronic inflammation,oxidative stress,endoplasmic reticulum and autophagy,and improving intestinal microflora disorder.

关 键 词：藏茵陈 有效成分 代谢综合征 肥胖 糖脂代谢 作用机制 

分 类 号：R965[医药卫生—药理学] R285.5[医药卫生—药学]