A novel traditional Chinese medicine combination for radiation  

作　　者：Ming Shang Yicheng Ke Jiangyun Liu Zhifei Cao Liying Zhang Wenyang Zhang Weiwei Pei Guangming Zhou Yongqi Liu 

机构地区：[1]Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities,Gansu University of Chinese Medicine,Lanzhou 730000,China [2]School of Radiation Medicine and Protection,Medical College of Soochow University,Suzhou 215123,China [3]Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions,Suzhou 215123,China [4]College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China [5]Department of Pathology,The Second Affiliated Hospital,Medical College of Soochow University,Suzhou 215123,China

出　　处：《Radiation Medicine and Protection》2024年第1期37-42,共6页放射医学与防护（英文）

基　　金：supported by the National Natural Science Foundation of China(82192883,82103786);the National Key R&D Program of China(2022YFA1104300);the National Space Science Center(YYWT-0801-EXP-12);the Postdoctoral Science Foundation of Jiangsu Province(7112851420),China.

摘　　要：Objective:To formulate an efficacious radioprotective combination of Chinese medicines with minimal toxicity.Methods:Aqueous and alcoholic extracts from 38 traditional Chinese herbs were prepared.To produce drugcontaining sera,rats received six doses of each extract via oral gavage at 12-h intervals.Subsequently,human lung epithelial BEAS-2B cells were cultured in these drug-containing sera.The cell viability was assessed after different doses of irradiation to identify the radioprotective effects of Chinese herbal extracts.The efficacy of a selected Chinese herbal extract combination was further confirmed through cell viability analysis via in vitro colony formation and survival rate assessments in C57BL/6 mice post-irradiation.Results:Extracts from Angelicae Sinensis Radix(ASR;two extracts),Citri Reticulatae Pericarpium(CRP),Platycladi Cacumen(PC),Schisandrae chinensis Fructus(SF),Scutellariae Radix(SR),and Glycyrrhizae Radix et Rhizome(GRR)demonstrated radioprotective effects.The combination of the seven Chinese herbal extracts notably increased the survival and viability of the BEAS-2B cells exposed to varying doses of X-rays.Moreover,the group of mice receiving Chinese medicine combination and irradiation exhibited prolonged survival after exposure to 6.5 Gy Xrays with a median survival of(14=2)d compared to(11=2)d in the irradiated group without the herbal treatment.Additionally,the Chinese medicine combination group displayed a significantly higher 28 d survival rate(30%)compared to the irradiation-only group(16.6%,P<0.05).Conclusion:The novel combination of Chinese herbal extracts from ASR,CRP,PC,SF,SR,and GRR has the potential for radiation protection applications.

关 键 词：Radiation protection Acute radiation syndrome Chinese medicine Drug-containing serum 

分 类 号：R815[医药卫生—放射医学]