新生儿缺氧缺血性脑损伤程序性细胞死亡及康复治疗干预机制的研究进展  

Research Progress of Mechanisms of Programmed Cell Death and Rehabilitation Intervention in Neonatal Hypoxic-Ischemic Brain Damage

作　　者：曾学究 展立芬 丁强盛 梁柔筠 艾坤[1] 周予婧 唐榕 易细芹 张泓[1] ZENG Xuejiu;ZHAN Lifen;DING Qiangsheng;LIANG Roujun;AI Kun;ZHOU Yujing;TANG Rong;YI Xiqin;ZHANG Hong(College of Acupuncture,Massage and Rehabilitation,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学针灸推拿与康复学院,长沙410208

出　　处：《医学综述》2024年第17期2060-2064,共5页Medical Recapitulate

基　　金：湖南省残疾人康复科研项目(2019XK017)。

摘　　要：新生儿缺氧缺血性脑损伤(HIBD)是一种脑细胞缺血缺氧性坏死病变,可导致神经发育性残疾,降低儿童生存质量,给患儿家庭及社会带来沉重负担。程序性细胞死亡(PCD)作为一种重要的神经元细胞死亡调控机制,参与HIBD的发生发展。康复治疗是改善HIBD后功能障碍的主要干预方式,临床应用广泛,但其效应机制目前尚未完全阐明。康复治疗可调控PCD,是促进HIBD后功能恢复的关键。因此,深入研究PCD特别是凋亡、自噬、焦亡、铁死亡在HIBD中的作用机制及康复干预机制,可以为疾病的治疗提供新思路。Neonatal hypoxic-ischemic brain damage(HIBD)is a kind of hypoxic-ischemic necrosis of brain cells,which can lead to neurodevelopmental disability,reduce the quality of life of children,and bring heavy burden to the families and society.As an important regulatory mechanism of neuronal cell death,programmed cell death(PCD)is involved in the occurrence and development of HIBD.Rehabilitation therapy is the main intervention to improve the dysfunction after HIBD,which is widely used in clinical practice,but its mechanism has not been fully elucidated.Rehabilitation therapy can regulate PCD,which is the key to promote functional recovery after HIBD.Therefore,in-depth studies of PCD,especially mechanisms of action of apoptosis,autophagy,pyroptosis,ferroptosis in HIBD and the mechanism of rehabilitation intervention can provide new ideas for the treatment of the disease.

关 键 词：缺氧缺血性脑损伤 新生儿 程序性细胞死亡 康复治疗 

分 类 号：R722.12[医药卫生—儿科] R493[医药卫生—临床医学]