生殖道微生物对子宫内膜容受性及体外受精-胚胎移植术妊娠结局的影响  

The impact of reproductive tract microorganisms on endometrial receptivity and pregnancy outcomes of in vitro fertilization and embryo transfer

作　　者：王荣 陈秀娟[1] WANG Rong;CHEN Xiujuan(Reproductive Center,the Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学附属医院生殖中心,内蒙古呼和浩特010000

出　　处：《中国医药科学》2024年第13期29-32,共4页China Medicine And Pharmacy

基　　金：内蒙古自治区自然科学基金项目(2023LHMS08054);内蒙古自治区科技计划项目(2021GG0389)。

摘　　要：子宫内膜容受性(ER)是影响辅助生殖技术(IVF)结局的关键因素,生殖道微生物影响ER。阴道微生物的研究显示乳杆菌是阴道优势菌群,对于维持阴道微环境稳定发挥重要作用。宫腔微生物的研究集中在慢性子宫内膜炎、肿瘤的病因相关性,对体外受精-胚胎移植术(IVF-ET)结局的相关性研究正在进行,乳酸杆菌为主(90%或以上)的微生物群有利于接受IVF-ET不孕妇女的胚胎着床,反之,非乳酸杆菌为主的细菌群体与不良妊娠结局,如胚胎种植失败及流产等有关。宫腔菌群失衡的原因及对ER的影响机制需要继续研究,如何调控宫腔微生物以利于IVF-ET的结局仍不确定,本文将阐述女性生殖道微生物的特征及其对女性健康和辅助生殖的影响,以促进生殖技术的发展。Endometrial receptivity(ER)is the key factor impacting the outcome of in vitro fertilization(IVF),and reproductive tract microorganisms affect ER.The research of vaginal microorganisms shows that the genus Lactobacillus is the dominant bacterial community in vagina,which plays an important role in maintaining the stability of vaginal microenvironment.The research on intrauterine microorganisms focuses on the etiology correlation between chronic endometritis and tumor,and the correlation research on the outcome of in vitro fertilization and embryo transfer(IVF-ET)is currently being studied.The microbiota dominated by lactobacillus(90%or more)is beneficial to the embryo implantation of infertile women undergoing IVF-ET,whereas the microbiota dominated by non-lactobacillus is related to adverse pregnancy outcomes such as embryo implantation failure and abortion.The reasons for the imbalance of intrauterine microbiota and its impact mechanism on ER need to be further studied,and how to regulate intrauterine microorganisms to facilitate the outcome of IVF-ET is still uncertain.This paper expound the characteristics of female reproductive tract microorganisms and their impact on women’s health and assisted reproduction,so as to promote the development of reproductive technology.

关 键 词：不孕 生殖道微生物 子宫内膜容受性 辅助生殖技术 

分 类 号：R714[医药卫生—妇产科学]