新生儿早发型B族溶血性链球菌感染的临床特点及相关影响因素分析  

Analysis of clinical characteristics and related impacting factors of early-onset group B streptococcus infection in neonates

作　　者：傅雅琨 FU Yakun(Department of Neonatology,South Branch of Fujian Provincial Hospital,Fujian,Fuzhou 350028,China)

机构地区：[1]福建省立医院南院新生儿科,福建福州350028

出　　处：《中国医药科学》2024年第13期103-107,共5页China Medicine And Pharmacy

摘　　要：目的探讨新生儿早发型B族溶血性链球菌感染(GBS-EOD)的临床表现特点,并对其相关影响因素进行全面分析。方法回顾性分析2015年10月至2023年6月福建省立医院南院收治的160例B族溶血性链球菌(GBS)感染新生患儿的临床资料,依据早发型与晚发型分为早发组(n=100)与晚发组(n=60)。通过两组的比较研究来突出新生儿GBS-EOD的临床表现特点。同时选取体重、胎龄等条件相同的非GBS感染新生患儿100例设为非GBS组,用以研究GBS-EOD的相关影响因素。结果早发组患儿脑膜炎的发生率为27.00%(27/100),肺炎的发生率为72.00%(72/100),败血症的发生率为70.00%(70/100);晚发组患儿脑膜炎的发生率为56.67%(34/60),肺炎的发生率为15.00%(9/60),败血症的发生率为85.00%(51/60)。晚发组以脑膜炎与败血症为主要的临床表现,早发组以肺炎与败血症为主要表现,两组临床表现比较,差异有统计学意义(P<0.05)。早发组和非GBS组的孕妇年龄、户籍、妊娠次数、孕周、早产、产程延长、宫内窘迫等临床资料比较,差异无统计学意义(P>0.05);母亲产前体温≥38℃、无预防性使用抗生素(IAP)、胎膜早破≥18 h、阴道分娩临床资料比较,差异有统计学意义(P<0.05)。logistic回归分析结果显示,母亲产前体温≥38℃、阴道分娩、无IAP、胎膜早破≥18 h是患儿GBS-EOD的危险因素(P<0.05)。结论新生儿GBSEOD以肺炎与败血症为主要的临床表现,并且母亲产前体温≥38℃、阴道分娩、无IAP、胎膜早破≥18 h是新生儿GBS-EOD的危险因素。Objective To explore the clinical presentation characteristics of neonates with early-onset group B streptococcal disease(GBS-EOD),as well as to conduct a comprehensive analysis of its related influencing factors.Methods The clinical data of 160 group B streptococcus(GBS)-infected neonates admitted to the South Hospital of Fujian Provincial Hospital from October 2015 to June 2023 were retrospectively analyzed and divided into the early-onset group(n=100)and the late-onset group(n=60)based on the early-onset and the late-onset groups,and the clinical manifestation characteristics of neonatal GBS-EOD were highlighted through the comparative study of the two groups.In addition,100 non-GBS-infected neonates with the same body mass and gestational age were selected to form the non-GBS group,which was used to study the influencing factors related to GBS-EOD.Results In the early-onset group,the incidence of meningitis was 27.00%(27/100),pneumonia was 72.00%(72/100),and sepsis was 70.00%(70/100).In the late-onset group,the incidence of meningitis was 56.67%(34/60),pneumonia was 15.00%(9/60),and the proportion of concomitant sepsis was 85.00%.sepsis was 85.00%(51/60).Compared with the early-onset group and the late-onset group,the late-onset group had meningitis and sepsis as the main clinical manifestations,while the early-onset group had pneumonia and sepsis as the main manifestations,and the difference between the clinical manifestations of the two groups was statistically significant(P<0.05),and the comparison of the clinical data of the early-onset group and the non-GBS group,such as the age of the pregnant women,household registration,the number of pregnancies,the gestational weeks,the preterm labor,prolongation of the labor process,intrauterine distress,etc.,were not statistically significant(P>0.05),while the comparison of clinical data such as mother’s prenatal temperature≥38℃,no intrapartum antibiotic prophylaxis(IAP),premature rupture of membranes≥18 h,and delivery methods showed statistically significa

关 键 词：危险因素 B族溶血性链球菌 新生儿 早发型 临床特征 

分 类 号：R722.1[医药卫生—儿科]