液-液相分离在心血管疾病中的研究进展  

Liquid-Liquid Phase Separation in Cardiovascular Disease

作　　者：黄佳宇 熊安琪 蒋弼瀛 陈文佳[1] HUANG Jiayu;XIONG Anqi;JIANG Biying;CHEN Wenjia(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2024年第7期603-607,共5页Advances in Cardiovascular Diseases

基　　金：黑龙江省博士后科研启动基金(LBH-Q20109);哈尔滨医科大学研究生科研和实践创新项目(YJSCX2023-192HYD)。

摘　　要：液-液相分离(LLPS)是指细胞中的生物大分子(如蛋白质、核酸等)在溶液中凝聚浓缩成液滴状从而形成不同液相的过程。该过程受到多种因素的调节,如翻译后修饰、氧化还原反应、温度、光度、离子浓度和伴侣蛋白等。LLPS是细胞生命活动中普遍存在且至关重要的现象,参与无膜细胞器的形成、基因转录调控、细胞信号转导和血管生成等过程。近年来,LLPS参与众多心血管疾病如动脉粥样硬化的发展、心肌纤维化的形成、心肌病的发生等。现对LLPS的生理机制以及在各种心血管疾病中的作用进行详细综述,旨在为心血管疾病的治疗提供新思路。Liquid-liquid phase separation(LLPS)refers to the process in which biological macromolecules(such as proteins,nucleic acids,etc.)in cells condense into droplets in solution to form different liquid phases.This process is regulated by many factors,such as post-translational modification,redox reaction,temperature,luminosity,ion concentration,chaperone protein and so on.LLPS is a ubiquitous and crucial phenomenon in cell life activities,which participates in the formation of membranous organelles,gene transcriptional regulation,cell signal transduction,angiogenesis and so on.In recent years,LLPS has been involved in many cardiovascular diseases,such as the development of atherosclerosis,the formation of myocardial fibrosis,the occurrence of cardiomyopathy and so on.This article provides a detailed review of the physiological mechanism of LLPS and its role in various cardiovascular diseases,aiming to provide new ideas for the treatment of cardiovascular diseases.

关 键 词：液-液相分离 心血管疾病 生物分子凝集体 动脉粥样硬化 心肌纤维化 

分 类 号：R54[医药卫生—心血管疾病]