不同病情程度肺结核患者血清α1-酸性糖蛋白和β干扰素的差异表达及其对疗效的预测  

Differential expression of serumα1-acid glycoprotein and interferon-βin patients with pulmonary tuberculosis of different severity and its value for the prediction of therapeutic effect

作　　者：李双良 陶艳 何蓉会 张昌艳 LI Shuangliang;TAO Yan;HE Ronghui;ZHANG Changyan(Department of Infectious Diseases,Nanchong Central Hospital,Nanchong 637003,Sichuan,China)

机构地区：[1]南充市中心医院感染病科,四川南充637003

出　　处：《中南医学科学杂志》2024年第4期582-584,共3页Medical Science Journal of Central South China

基　　金：四川省基层卫生事业发展研究中心项目(SWFZ2022-Y-17)。

摘　　要：目的探究不同病情程度肺结核患者血清α1-酸性糖蛋白(AAG)和β干扰素(IFN-β)的差异表达及其对疗效的预测。方法选取120例肺结核患者为研究组,根据病情分为稳定期组和活动期组;根据治疗效果分为无效组和有效组。另选取同期进行治疗的普通肺炎患者120例为对照组。比较各组患者血清AAG和IFN-β水平。诊断试验和ROC分析检测AAG和INF-β对肺结核疗效的预测价值。结果血清AAG、IFN-β水平研究组低于对照组,活动期组低于稳定期组,无效组低于有效组(P<0.05)。联合诊断效能分析显示,血清AAG和IFN-β联合检测对疗效预测的灵敏度显著高于单独检测。ROC分析结果显示,血清AAG和IFN-β联合检测对疗效预测的曲线下面积显著高于单独检测。结论不同病情程度肺结核患者血清AAG和IFN-β呈现显著差异,血清AAG和IFN-β联合检测对患者疗效具有良好预测价值。Aim To explore the differential expression of serumα1-acid glycoprotein(AAG)and interferon-β(IFN-β)in patients with pulmonary tuberculosis of different disease degrees and the value for the prediction of therapeutic effect.Methods 120 patients with pulmonary tuberculosis were selected as the study group,and divided into stable phase group and active phase group based on their condition,or divide into ineffective group and effective group based on treatment effectiveness.Another 120 patients with common pneumonia who underwent treatment at the same time were selected as the control group.The different levels of serum AAG and IFN-βof patients in each group were compared.The diagnostic tests and ROC analysis were used to analyze the predictive value of the detection indicators for the therapeutic efficacy of pulmonary tuberculosis.Results Serum AAG and IFN-βin the study group was lower than the control group,the active period group was lower than the stable period group,and the ineffective group was lower than the effective group(P<0.05).Joint diagnostic efficacy analysis showed that joint testing for serum AAG and IFN-βhad significantly higher predictive sensitivity compared with single testing.The ROC curve analysis results showed that joint detection of serum AAG and IFN-βhad significantly larger area under the curve for efficacy prediction compared with single testing.Conclusion Serum AAG and IFN-βlevels showed significant differences in patients with pulmonary tuberculosis of different severity,and joint testing of serum AAG and IFN-βlevels has good predictive value for patient therapeutic effects.

关 键 词：肺结核 AAG IFN-Β 联合检测 

分 类 号：R521[医药卫生—内科学]