细菌性肺炎患者血清LTB4、NLCR及CRP/PA变化及其与肺损伤程度的关系  

Changes of serum LTB4,NLCR and CRP/PA ratio,and their relationship with the severity of lung injury in patients with pneumonia induced by bacterial infection

作　　者：张春红[1] 程波[1] 曹建[1] ZHANG Chunhong;CHENG Bo;CAO Jian(Department of Laboratory Medicine,Neijiang First People's Hospital,Neijiang 641000,Sichuan,China)

机构地区：[1]内江市第一人民医院检验科,四川内江641000

出　　处：《中南医学科学杂志》2024年第4期596-598,672,共4页Medical Science Journal of Central South China

基　　金：四川省医学科研课题(S22009)。

摘　　要：目的探讨细菌性肺炎患者血清白三烯B4(LTB4)、中性粒细胞/淋巴细胞计数比值(NLCR)及C-反应蛋白与前白蛋白(CRP/PA)比值变化及其与肺损伤程度的关系。方法回顾性选取172例细菌性肺炎患者(观察组)和同期140例健康体检者(对照组)的临床资料,根据肺损伤程度,将患者分为轻中度组和重度组。比较各组LTB4、NLCR及CRP/PA水平,分析LTB4、NLCR及CRP/PA联合评估患者肺损伤程度的价值。结果与对照组比较,观察组LTB4、NLCR及CRP/PA水平更高(P<0.05);与轻中度组比较,重度组LTB4、NLCR及CRP/PA水平更高(P<0.05);ROC结果显示,LTB4、NLCR和CRP/PA评估患者肺损伤程度的AUC为0.793、0.717、0.758,三者联合评估患者肺损伤程度的AUC为0.933,高于单项评估(P<0.05)。结论LTB4、NLCR及CRP/PA在细菌性肺炎患者中表达水平均会升高,且其均与肺损伤程度有关,其联合评估肺损伤程度的价值较高。Aim To explore the changes of serum leukotriene B4(LTB4),neutrophil/lymphocyte count ratio(NLCR)and C-reactive protein/prealbumin(CRP/PA)ratio,and their relationship with the severity of lung injury in patients with pneumonia induced by bacterial infection(bacterial pneumonia).Methods A retrospective collection was performed based on the clinical data of 172 patients with bacterial pneumonia(observation group)and 140 healthy controls(control group).According to the severity of lung injury,patients were divided into mild-moderate group and severe group.The levels of LTB4,NLCR and CRP/PA ratio in different groups were compared,and the evaluation value of combination of these parameters in the detection of the severity of lung injury was analyzed.Results Compared with control group,levels of LTB4,NLCR and CRP/PA ratio were higher than those in observation group(P<0.05).Compared with mild-moderate group,levels of LTB4,NLCR and CRP/PA ratio were higher than those in severe group(P<0.05).The results of ROC curves analysis showed that AUC of LTB4,NLCR and CRP/PA ratio for evaluating the severity of lung injury were 0.793,0.717,and 0.758,respectively.AUC of combined detection was 0.933,greater than that of single evaulation(P<0.05).Conclusion The expressions of LTB4,NLCR and CRP/PA ratio are up-regulated in patients with bacterial pneumonia.LTB4,NLCR and CRP/PA ratio are all related to the severity of lung injury,and combined detection has higher evaluation value.

关 键 词：细菌性肺炎 白三烯B4 中性粒细胞/淋巴细胞计数比值 C-反应蛋白/前白蛋白 肺损伤程度 

分 类 号：R563.11[医药卫生—呼吸系统]