柴归颗粒对水瘀互结型Ⅲ型前列腺炎患者的影响  

Effect of Chaigui Granule on Cytokines in Prostatic Fluid of Type Ⅲ Prostatitis

作　　者：李刚琴 蒋霖[1] 白宽 谭广兴[1] LI Gangqin;JIANG Lin;BAI Kuan;TAN Guangxing(Traditional Chinese Medicine Hospital of Wuxi,Wuxi 214071,China)

机构地区：[1]无锡市中医医院,江苏无锡214071

出　　处：《云南中医药大学学报》2024年第3期8-12,共5页Journal of Yunnan University of Chinese Medicine

基　　金：无锡市中医药管理局科技项目(ZYKJ202018)。

摘　　要：目的观察柴归颗粒治疗Ⅲ型前列腺炎水瘀互结证患者的临床疗效及对前列腺液细胞因子等指标的影响。方法将水瘀互结型Ⅲ型前列腺炎患者随机分为治疗组(35例)与对照组(27例)。对照组予盐酸坦索罗辛缓释胶囊口服,治疗组予柴归颗粒口服。比较2组患者治疗前后慢性前列腺炎症状指数(NIH-CPSI)评分、前列腺液细胞因子变化情况及临床疗效。结果治疗组在接受治疗后,其NIH-CPSI评分明显降低,与治疗前相比存在显著差异(P<0.05)。此外,与对照组相比治疗组治疗后的NIH-CPSI评分明显降低(P<0.05)。在对照组中,治疗后的IL-2水平与该组治疗前相比存在统计学意义的差异(P<0.05)。治疗后,治疗组的IL-2、IL-6、IL-8水平显著降低(P<0.05),且与对照组相比,IL-2、IL-6水平更低(P<0.05)。治疗组的中医证候总有效率明显高于对照组(P<0.05)。结论柴归颗粒能明显改善Ⅲ型前列腺炎水瘀互结证患者临床症状,提高临床疗效,其机制可能与调节前列腺液细胞因子水平有关,值得进一步研究。Objective To observe the clinical efficacy of Chaigui granules in the treatment of type III prostatitis with water stasis syndrome and its impact on prostate fluid cytokines and other indicators.Methods Patients diagnosed with water stasis type III prostatitis were randomly assigned to either a treatment group consisting of 35 cases or a control group comprising 27 cases.The control group was given sustained-release capsules of tamsulosin hydrochloride orally,while the treatment group was given Chaigui granules orally.Compare the chronic prostatitis symptom Index(NIH-CPSI)score,changes in prostate fluid cytokines,and clinical efficacy between two groups of patients before and after treatment.Results The national institutes of health chronic prostatitis symptom index(NIH-CPSI)scores in the treatment group showed a significant reduction after the treatment when compared to their scores before treatment(P<0.05).This decrease was also notably greater than the scores in the control group after treatment.Additionally,the levels of interleukins IL-2,IL-6,and IL-8 in the treatment group showed a significant reduction post-treatment compared to their levels before treatment(P<0.05).The levels of IL-2 and IL-6 were significantly lower in the treatment group than in the control group post-treatment.Furthermore,when comparing the total effectiveness rates of traditional Chinese medicine syndromes between the two groups,the treatment group demonstrated a significantly higher effectiveness rate than the control group(P<0.05).Conclusion Chaigui granules can significantly improve the clinical symptoms of patients with type III prostatitis with water stasis syndrome,and enhance clinical efficacy.Its mechanism may be related to the regulation of cytokine levels in prostate fluid,which is worth further research.

关 键 词：柴归颗粒 Ⅲ型前列腺炎 水瘀互结证 前列腺液 细胞因子 

分 类 号：R277.5[医药卫生—中医学]