妊娠合并卵巢恶性肿瘤的临床分析  

Clinical analysis of pregnancy complicated with malignant ovarian tumors

作　　者：汪志辉[1] 林晓玲 吴晓健 胡勤斐 生秀杰[1] Zhihui Wang;Xiaoling Lin;Xiaojian Wu;Qinfei Hu;Xiujie Sheng(Department of Gynecology,The Third Affiliated Hospital of Guangzhou Medical University,Guangdong Key Laboratory of Major Diseases of Obstetrics,Guangdong Clinical Medical Research Center of Obstetrics and Gynecology,Joint Laboratory of Maternal-Fetal Medicine Universities of Guangdong,Hong Kong and Macao,Guangzhou 510150,China)

机构地区：[1]广州医科大学附属第三医院妇科,广东省产科重大疾病重点实验室,广东省妇产疾病临床医学研究中心,粤港澳母胎医学高校联合实验室,广州市510150

出　　处：《中国肿瘤临床》2024年第10期506-509,共4页Chinese Journal of Clinical Oncology

基　　金：广州市一般引导项目(编号:20231A011095)资助。

摘　　要：目的:探讨妊娠合并卵巢恶性肿瘤患者的临床特点、治疗方案及妊娠结局。方法:回顾性分析2012年1月至2022年12月在广州医科大学附属第三医院就诊的11例妊娠合并卵巢恶性肿瘤患者的病理类型、临床分期、手术方式、妊娠结局、随访结果等临床资料。结果:11例患者随访至2023年10月,其中卵巢原发肿瘤6例,卵巢转移性肿瘤5例。6例卵巢原发肿瘤中,上皮性肿瘤5例(ⅠA期1例,ⅠC期2例,ⅢA期1例,ⅢB期1例),恶性生殖细胞肿瘤1例(ⅠA期);Ⅰ期4例,孕早期发现1例,要求继续妊娠,分娩后行分期手术,孕晚期发现3例,剖宫产同时或产后行分期手术;Ⅲ期2例,孕早期发现1例,终止妊娠后行分期手术,孕晚期发现1例,剖宫产同时行分期手术;5例成功分娩,早产2例,足月产3例,新生儿均健在;随访时间为18~133个月,均生存。卵巢转移性肿瘤5例,其中卵巢Krukerberg瘤4例,子宫颈癌卵巢转移1例;孕早期发现2例,均终止妊娠后行减瘤术;孕中期发现1例,要求继续妊娠,分娩后行减瘤术;孕晚期发现2例,剖宫产同时行卵巢肿物手术1例,产后行减瘤术1例;成功分娩3例,均为早产,均健在;失访1例,余4例随访时间为3~22个月,均死亡。结论:妊娠合并卵巢原发肿瘤预后较好,而妊娠合并卵巢转移性肿瘤恶性程度高、预后差,临床应引起重视。Objective:To explore the clinical characteristics,treatments,and pregnancy outcomes of pregnant women with malignant ovari-an tumors.Methods:We retrospectively analyzed the clinical data of 11 patients with pregnancies complicated by malignant ovarian tu-mors,including the pathological types,clinical staging,surgical methods,pregnancy outcomes,and follow-up results from January 2012 to December 2022.Results:Among the eleven patients followed up until October 2023,six had primary ovarian tumors and five had metastat-ic ovarian tumors.Among the six primary ovarian tumors,five were epithelial tumors(one in stageⅠA,two in stageⅠC,one in stageⅢA,one in stageⅡB)and one was a malignant germ cell tumor(stageⅠA).Four patients were diagnosed at stageⅠ:one in early pregnancy who continued the pregnancy and underwent tumor surgery post-delivery,and three in late pregnancy who under went tumor surgery dur-ing cesarean section or postpartum.Two patients were diagnosed at stageⅢ:one in early pregnancy with surgery after the termination of pregnancy,and one in late pregnancy with surgery during a cesarean section.Five patients had successful births,including two premature and three full-term births,all alive and healthy.The six patients with primary ovarian tumors were followed up for 18–133 months,and all survived.Five patients had ovarian metastatic tumors,including four cases of Krukenberg tumors and one of a cervical tumor.Two patients were diagnosed in the first trimester and underwent tumor reduction post-abortion.One patient was diagnosed in the second trimester,had to continue the pregnancy,and underwent tumor reduction post-delivery.Two patients were diagnosed in the third trimester:one under-went cesarean section and ovarian tumor resection simultaneously,and the other underwent tumor resection post-delivery.Three patients had successful births,all premature but alive.One of the five patients with ovarian metastatic tumors was lost to follow-up;the remaining four were followed up for 3–22 months,and a

关 键 词：妊娠期 卵巢恶性肿瘤 临床特点 治疗 

分 类 号：R714.25[医药卫生—妇产科学] R737.31[医药卫生—临床医学]