酸枣仁及其提取物治疗失眠的药理机制研究进展  

Research progress on the pharmacological mechanism of Semen ziziphi spinosae and its extract in treating insomnia

作　　者：方书德 陈巧巧 FANG Shude;CHEN Qiaoqiao(Department of Preventive Medicine,Wangjiang County Traditional Chinese Medicine Hospital,Anqing 246200,China)

机构地区：[1]安徽省安庆市望江县中医医院治未病科,246200

出　　处：《环球中医药》2024年第7期1440-1445,共6页Global Traditional Chinese Medicine

摘　　要：酸枣仁提取物通过调节下丘脑γ-氨基丁酸能突触通路、5-羟色胺能突触通路、下丘脑黑色素聚集激素、食欲素A等神经递质的表达,以调节睡眠—觉醒平衡,发挥抗失眠作用。酸枣仁提取物通过调节下丘脑能量代谢,改善肝代谢功能,调节血清代谢物分泌,改善心肌线粒体功能,以维持机体能量代谢平衡,改善大脑睡眠节律调节功能。酸枣仁醇提取物可纠正下丘脑—垂体—肾上腺轴功能紊乱,纠正睡眠相关激素的分泌,调节睡眠结构,发挥催眠作用。酸枣仁提取物可改善免疫功能,显著降低多种炎症因子的释放,纠正神经—内分泌—免疫调节功能紊乱,以减轻睡眠障碍。Semen ziziphi spinosae kernel can regulate the synaptic pathway ofγ-aminobutyric acid(GABA)in the hypothalamus,5-hydroxytryptamine(5-HT),which can regulate the sleep-wake balance and play an anti-insomnia role in the expression of synaptic pathways,melanin-concentrating hormone(MCH),Orexin-A and other neurotransmitters in the hypothalamus.Semen ziziphi spinosae kernel can regulate hypothalamic energy metabolism,improve liver metabolism,regulate serum metabolite secretion,improve myocardial mitochondrial function,maintain energy metabolism balance,and improve brain sleep rhythm regulation function.Semen ziziphi spinosae kernel can correct the dysfunction of HPA axis,correct the secretion of sleep-related hormones,regulate sleep structure,and play a hypnotic role.Semen ziziphi spinosae kernel can improve immune function,reduce the release of a variety of inflammatory factors,correct neuro-endocrine-immune regulatory dysfunction,and alleviate sleep disorders.

关 键 词：酸枣仁 酸枣仁皂苷 失眠 Γ-氨基丁酸 5-羟色胺 肝功能 免疫功能 单胺神经递质 

分 类 号：R285[医药卫生—中药学]