基于数据生命周期的国家临床医学研究中心数据平台建设  

Establishment of national clinical medical research center data platform based on data life cycle

作　　者：杨钟力 王洋 夏鑫 董碧蓉[1] Yang Zhongli;Wang Yang;Xia Xin;Dong Birong(National Clinical Research Center for Geriatrics,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院国家老年疾病临床医学研究中心,成都610041

出　　处：《中华医院管理杂志》2024年第4期298-304,共7页Chinese Journal of Hospital Administration

基　　金：四川大学华西医院学科卓越发展1·3·5工程项目(ZYGD20010)。

摘　　要：大数据和人工智能技术的迅速发展推动了大规模、多中心和多形式的临床研究开展,而如何高效整合利用临床研究数据资源成为了亟须解决的问题。国家老年疾病临床医学研究中心基于美国地质调查局提出的科学数据生命周期模型,设计"S-C-V-C-R-A"数据管理平台框架,确定标准化(standardization)、可控(controllable)、可见(visible)、可信(credible)、可靠(reliable)、可得(available)6项数据管理原则,通过解决数据聚合、数据标准化和数据共享3项关键技术,搭建一体化临床科研数据平台,实现数据的管理计划标准化、获取可控、处理可见、分析可信、存储可靠、发布与共享可得,解决了数据质量差、利用效率低、安全性低、共享难的问题。截至2023年7月,该平台已聚合487096例老年临床病例数据,开展10余项科研项目,支撑200余家协同创新网络单位,建设4个老年特色人群队列。该平台实现了数据管理计划、获取、处理、分析、保存、发布与共享的全流程一站式服务,提升了科研效率,促进了协同研究和数据共享。The rapid development of big data and artificial intelligence technologies has propelled the large-scale,multi-center,and diverse forms of clinical research,and how to efficiently integrate and utilize clinical research data resources has become an urgent problem to be solved.Based on the U.S.geological survey(USGS)scientific data life cycle model,the National Clinical Research Center for Geriatrics has devised the"S-C-V-C-R-A"data management platform framework,which determined six data management principles:Standardization,Controllability,Visibility,Credibility,Reliability,and Availability.By solving three key technologies:data aggregation,data standardization,and data sharing,an integrated clinical research data platform was built to realize standardized data management plans,controllable data acquisition,visible data processing,credible data analysis,reliable data storage,and accessible data publication and sharing.As of July 2023,the platform has aggregated data from 487096 elderly patients,carried out more than 10 scientific research projects,supported over 200 collaborative innovation network units,and established four cohorts of elderly populations with distinct characteristics.The platform has achieved a one-stop,comprehensive service of data management planning,acquisition,processing,analysis,storage,publication,and sharing,thus achieving the objectives of enhancing research efficiency,promoting collaborative research,and facilitating data sharing.

关 键 词：数据库 数据生命周期模型 国家临床医学研究中心 一体化科研数据平台 临床科研 

分 类 号：TP311.13[自动化与计算机技术—计算机软件与理论] R-05[自动化与计算机技术—计算机科学与技术]