甲状腺功能亢进症患者血清果糖胺、糖化血红蛋白水平及其与糖代谢指标水平的相关性  

Serum fructosamine and glycosylated hemoglobin levels in patients with hyperthyroidism and their correlation with glucose metabolism indexes

作　　者：邢琪 常文龙[1] 翟娜 XING Qi;CHANG Wenlong;ZHAI Na(Department of Endocrine Laboratory,Baoding First Central Hospital,Baoding,Hebei 071000,China;the First Department of Endocrinology,Baoding First Central Hospital,Baoding,Hebei 071000,China)

机构地区：[1]保定市第一中心医院内分泌实验室,河北保定071000 [2]保定市第一中心医院内分泌一科,河北保定071000

出　　处：《检验医学与临床》2024年第15期2168-2171,共4页Laboratory Medicine and Clinic

基　　金：河北省保定市科技计划项目(2241ZF231)。

摘　　要：目的探讨甲状腺功能亢进症患者血清果糖胺(FMN)和糖化血红蛋白(HbA1c)水平及其与糖代谢指标水平的相关性。方法选取2021年1月至2022年9月该院收治的127例甲状腺功能亢进症患者作为研究组,另选取同期在该院体检且一般资料与甲状腺功能亢进症患者相匹配的127例健康者作为对照组。采用Pearson相关分析血清FMN、HbA1c水平与糖代谢指标水平的相关性;采用多因素Logistic回归分析甲状腺功能亢进症发生的危险因素。结果研究组与对照组空腹血糖(FPG)、空腹血胰岛素(FIns)、胰岛素抵抗指数(HOMA-IR)、FMN和HbA1c水平比较,差异均有统计学意义(P<0.05);甲状腺功能亢进症患者血清FMN和HbA1c水平与FPG、FIns及HOMA-IR水平均呈正相关(P<0.05);FPG、HOMA-IR、FMN及HbA1c水平升高均为甲状腺功能亢进症发生的危险因素(P<0.05)。结论甲状腺功能亢进症患者血清FMN和HbA1c水平均升高,且与糖代谢指标水平具有相关性。Objective To investigate the serum fructosamine(FMN)and glycosylated hemoglobin(HbA1c)in patients with hyperthyroidism and their correlation with glucose metabolism indexes.Methods A total of 127 patients with hyperthyroidism admitted to the hospital from January 2021 to September 2022 were selected as the study group,and 127 healthy people who underwent physical examination in the hospital during the same period and whose general data were matched with hyperthyroidism patients were selected as the control group.Pearson correlation analysis was used to analyze the correlation between serum FMN,HbA1c levels and glucose metabolism indicators.Multivariate Logistic regression was used to analyze the risk factors of hyperthyroidism.Results There were significant differences in the levels of fasting plasma glucose(FPG),fasting insulin(Fins),HOMA-IR,FMN and HbA1c between the study group and the control group(P<0.05).Serum FMN and HbA1c levels were positively correlated with FPG,FIns and HOMA-IR levels in patients with hyperthyroidism(P<0.05).The increased levels of FPG,HOMA-IR,FMN and HbA1c were risk factors for hyperthyroidism(P<0.05).Conclusion The levels of serum FMN and HbA1c in patients with hyperthyroidism increase,and are correlated with the levels of glucose metabolism indicators.

关 键 词：甲状腺功能亢进症 果糖胺 糖化血红蛋白 糖代谢 空腹血糖 空腹血胰岛素 胰岛素抵抗指数 

分 类 号：R581.1[医药卫生—内分泌] R589[医药卫生—内科学] R446.1[医药卫生—临床医学]