PCSK9促炎作用在动脉粥样硬化中的研究进展  

Advances in the pro-inflammatory role of PCSK9 in atherosclerosis

作　　者：万正韵 李红薇 王炼(综述)[1] 严喜胜(审校) WAN Zhengyun;LI Hongwei;WANG Lian;YAN Xisheng(School of Medicine,Wuhan University of Science and Technology,Wuhan,Hubei 430065,China;Department of Cardiology,Wuhan Third Hospital,Wuhan,Hubei 430060,China)

机构地区：[1]武汉科技大学医学部医学院,湖北武汉430065 [2]武汉市第三医院心内科,湖北武汉430060

出　　处：《检验医学与临床》2024年第15期2288-2291,共4页Laboratory Medicine and Clinic

基　　金：湖北省科技计划项目(2020CFB660)。

摘　　要：动脉粥样硬化(AS)是以大中动脉中形成富含脂质及免疫细胞斑块为特征的病理状态,其中斑块破裂会形成血栓,阻碍动脉及血流,最终导致急性心血管事件。前蛋白转化酶枯草杆菌蛋白酶/kexin9(PCSK9)作为调节血浆胆固醇水平的关键因子,其促炎作用可能会加剧这一过程。该文通过分析PCSK9的结构与功能、AS中的炎症反应过程,PCSK9如何影响AS中相关的炎症细胞、炎症因子、信号通路来促进AS的发生和发展,以及PCSK9抑制剂的抗炎作用的相关证据,揭示了PCSK9作为新型炎症反应和AS治疗靶点的潜力。PCSK9的促炎特性在AS中有重要作用。目前关于PCSK9促进AS炎症反应的研究尚不完全,未来需要继续探索PCSK9在AS中的促炎作用机制,有助于开发新的治疗策略,比如小分子药物或基因疗法,为心血管疾病患者提供更全面的治疗选择。基于PCSK9作用的多效性,PCSK9抑制剂的新适应证正在出现,将进一步扩大靶向PCSK9的潜力。Atherosclerosis(AS)is a large and medium-sized artery plaque formation is rich in lipid and immune cells in pathological state,characterized with plaque rupture can form thrombus,clog arteries and blocking blood flow,eventually leading to acute cardiovascular events.This process may be exacerbated by the proinflammatory effects of proprotein convertase subtilisin/kexin9(PCSK9),a key factor regulating plasma cholesterol levels.This article analyzes the structure and function of PCSK9,the inflammatory response process in AS,how PCSK9 affects inflammatory cells,inflammatory factors and signaling pathways in AS to promote the occurrence and development of AS,and the anti-inflammatory effect of PCSK9 inhibitors,revealing the potential of PCSK9 as a new therapeutic target for inflammation and AS.The proinflammatory properties of PCSK9 play an important role in AS.The current research on PCSK9 promote AS inflammation is not fully,the future need to continue to explore the PCSK9 in AS proinflammatory role mechanism,contribute to the development of new treatment strategies,such as small molecule drug or gene therapy,treatment options for patients with cardiovascular disease to provide more comprehensive.On the basis of the pleiotropic effects of PCSK9,new indications for PCSK9 inhibitors are emerging that will further expand the potential for targeting PCSK9.

关 键 词：前蛋白转化酶枯草杆菌蛋白酶/kexin9 动脉粥样硬化 炎症反应 前蛋白转化酶枯草杆菌蛋白酶/kexin9抑制剂 斑块破裂 血栓 

分 类 号：R543.5[医药卫生—心血管疾病] R446.1[医药卫生—内科学]