益气活血汤治疗不稳定型心绞痛老年患者的疗效及对其血流动力学和心电图的影响  

Yiqi Huoxue Decoction for Unstable Angina Pectoris in Elderly Patients:Therapeutic Effect and Influences on Hlemodynamics and Electrocardiogram

作　　者：马晓妍[1] 金鑫[1] 钟雪焱[1] 卢成华 MA Xiao-yan;JIN Xin;ZHONG Xue-yan;LU Cheng-hua(Department of Geriatrics,Center for Geriatrics,Dalian Friendship Hospital,Dalian Liaoning 116000)

机构地区：[1]大连市友谊医院老年医学中心老年病科,辽宁大连116000

出　　处：《世界中西医结合杂志》2024年第7期1343-1346,1353,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：大连市科技计划项目(2014E14SF153)。

摘　　要：目的探究益气活血汤对不稳定型心绞痛(Unstable angina pectoris,UAP)老年患者的疗效及对其血流动力学和心电图的影响。方法选取2019年5月-2022年6月期间大连市友谊医院老年医学中心老年病科收治的92例UAP老年患者,按随机数字表法分为对照组和观察组,每组各46例。对照组给予常规治疗,观察组在对照组基础上给予益气活血汤治疗,均持续治疗4周。观察比较两组患者临床疗效、心电图改善情况,治疗前后血脂[总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)]水平、血流动力学(全血还原黏度、纤维蛋白原、红细胞聚集指数、血浆黏度)指标及不良反应发生情况。结果治疗后观察组临床总有效率91.30%(42/46)明显高于对照组73.91%(34/46),差异有统计学意义(P<0.05)。治疗后两组患者血脂TC、TG、LDL-C水平均较治疗前降低,HDL-C水平较治疗前升高,差异有统计学意义(P<0.05);且观察组TC、TG、LDL-C水平均明显低于对照组,HDL-C水平明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者全血还原黏度、红细胞聚集指数、纤维蛋白原、血浆黏度均较治疗前降低,差异有统计学意义(P<0.05);且观察组血流动力学指标明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组心电图改善总有效率86.96%(40/46)明显高于对照组67.39%(31/46),差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论益气活血汤治疗老年UAP的疗效显著,可有效改善患者血流动力学指标和心电图情况。Objective To explore the therapeutic effect of Yiqi Huoxue Decoction on unstable angina pectoris(UAP)in elderly patients and the influences of the treatment on hemodynamics and electrocardiogram(ECG).Methods A total of 92 elderly patients with UAP treated in the Department of Geriatrics,Center for Geriatrics,Dalian Friendship Hospital from May 2019 to June 2022 were selected and assigned with the random number table method into control and observation groups(n=46).The control group received conventional treatment,and the observation group received Yiqi Huoxue Decoction on the basis of conventional treatment.The treatment lasted for four weeks in both groups.The clinical efficacy and ECG improvement were compared between the two groups.The levels of blood lipids[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)],as well as haemodynamic parameters[whole blood viscosity,fibrinogen,erythrocyte aggregation index,and plasma viscosity],were measured before and after treatment.The occurrence of adverse reactions was recorded and compared between the two groups.Results After treatment,the total response rate in the observation group was 91.30%(42/46),which was higher than that(73.91%,34/46)in the control group(P<0.05).The treatment lowered the levels of TC,TG,and LDL-C and elevated the level of HDL-C(P<0.05),and the observation group had lower levels of TC,TG,and LDL-C and higher level of HDL-C than the control group after treatment(P<0.05).After treatment,the whole blood viscosity,erythrocyte aggregation index,fibrinogen,and plasma viscosity declined in both groups(P<0.05),and the observation group had lower hemodynamic indexes than the control group(P<0.05).The total response rate of ECG improvement in the observation group was 86.96%(40/46),which was higher than that(67.39%,31/46)in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during the treatment period(P>0.05).C

关 键 词：益气活血汤 不稳定型心绞痛 临床疗效 血流动力学 心电图 

分 类 号：R541.4[医药卫生—心血管疾病]