调补脾肾法配合西医对症治疗肥胖型多囊卵巢综合征患者的疗效观察  

Therapeutic Effect of Spleen-and Kidney-Tonifying Method Combined with Western Medicine on Obese Patients with Polycystic Ovarian Syndrome

作　　者：张成奇[1] 闫柳佳 刘博 荀军锋 王娟[1] 段俊红[1] ZHANG Cheng-qi;YAN Liu-jia;LIU Bo;XUN Jun-feng;WANG Juan;DUAN Jun-hong(Department of Endocrinology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050000)

机构地区：[1]河北省石家庄市中医院内分泌,河北石家庄050000

出　　处：《世界中西医结合杂志》2024年第7期1426-1431,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研项目(2019444)。

摘　　要：目的观察调补脾肾法配合西医对症治疗肥胖型多囊卵巢综合征(Polycystic ovary syndrome,PCOS)患者的临床疗效。方法选取2020年6月-2022年6月期间石家庄市中医院妇产科就诊的80例PCOS患者,根据入院顺序随机分为对照组和观察组,每组各40例。对照组给予常规治疗,观察组在对照组基础上以调补脾肾法立方口服治疗。治疗6个月后,观察比较两组患者临床疗效,治疗前后中医证候积分、血清激素[雌二醇(Estradiol2,E_(2))、促黄体生成素(Luteinizing hormone,LH)、睾酮(Androstenedione,T)、促卵泡生成素(Follicle stimulating hormone,FSH)]水平、血脂指标[总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)]、氧化应激指标[血清丙二醛(Malondialdehyde,MDA)及超氧化物歧化酶(Superoxide dismutase,SOD)]、体质量指数(Body mass index,BMI)及腰臀比(Waist hip ratio,WHR)。结果治疗后两组患者中医证候积分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者BMI及WHR指数均较治疗前降低,差异有统计学意义(P<0.05);且观察组BMI、WHR指数均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者E_(2)、LH及T水平均较治疗前降低,FSH水平均较治疗前升高,差异有统计学意义(P<0.05);且观察组E_(2)、LH及T水平均明显低于对照组,FSH水平明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者TC、TG及LDL-C水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组TC、TG及LDL-C水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者MDA水平均较治疗前降低,SOD水平均较治疗前明显升高,差异有统计学意义(P<0.05);且观察组MDA水平明显低于对照组,SOD水平明显高于对照组,差异有统计学意义(P<0.05)。治�Objective To observe the therapeutic effect of spleen-and kidney-tonifying method combined with Western medicine on obese patients with polycystic ovary syndrome(PCOS).Methods Eighty obese patients with PCOS treated in the Obstetrics and Gynecology Department of Shijiazhuang Hospital of Traditional Chinese Medicine from June 2020 to June 2022 were selected and randomized into a control group and an observation group,with 40 patients in each group.The control group received conventional treatment,while the observation group was treated with the formula for tonifying the spleen and kidney on the basis of the therapy in the control group.The therapeutic effect was compared between the two groups after 6 months of treatment.The traditional Chinese medicine(TCM)symptom scores,serum levels of hormones[estradiol(E_(2)),luteinizing hormone(LH),testosterone(T),and follicle-stimulating hormone(FSH)],levels of blood lipids[total cholesterol(TC),triglyceride(TG),and low density lipoprotein-cholesterol(LDL-C)],oxidative stress indicators[malondialdehyde(MDA)and superoxide dismutase(SOD)],body mass index(BMI),and waist-to-hip ratio(WHR)were measured before and after treatment.Results The TCM symptom scores,BMI,and WHR in both groups declined after treatment(P<0.05),and the observation group had lower TCM symptom scores,BMI,and WHR than the control group(P<0.05).After treatment,the levels of E_(2),LH,and T declined and that of FSH elevated in both groups(P<0.05),and the observation group had lower E_(2),LH,and T level and higher FSH level than the control group(P<0.05).After treatment,the levels of TC,TG,and LDL-C in both groups became lowered(P<0.05)and were lower in the observation group than in the control group(P<0.05).The treatment lowered the MDA level and elevated the SOD level in both groups(P<0.05),and the changes in the observation group were more obvious than those in the control group(P<0.05).The total response rate in the observation group was 92.50%(37/40),which was higher than that(75.00%,30/40)in the control gro

关 键 词：调补脾肾 肥胖 多囊卵巢综合征 氧化应激 

分 类 号：R588.6[医药卫生—内分泌]