泰安地区耐万古霉素肠球菌患者的现况调查  

A Study of the Status of Patients with Vancomycin-resistant Enterococci in Tai’an

作　　者：王晓蕾 王波[1] 潘晓 陈金芝 WANG Xiaolei;WANG Bo;PAN Xiao;CHEN Jinzhi(Tai’an Hospital of Traditional Chinese Medicine,Tai’an 271000,China;不详)

机构地区：[1]泰安市中医医院,山东泰安271000 [2]山东第一医科大学

出　　处：《中外医学研究》2024年第19期167-172,共6页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：山东省医务职工科技创新计划项目(SDYWZGKCJHLH202273)。

摘　　要：目的:研究泰安地区耐万古霉素肠球菌患者的临床特征及其耐药情况。方法:收集自2019年1月—2022年12月于泰安市中医医院的住院感染患者标本,包括血液,尿液,腹水等的细菌培养,共335例。根据其药敏结果分为两组,其中万古霉素耐药肠球菌(vancomycin-resistant enterococcus,VRE)组37例,万古霉素敏感的肠球菌(vancomycin-sensitive enterococcus,VSE)组298例。根据病历,提取患者临床资料,包括性别、年龄、科室等。收集本科室的细菌鉴定及药敏结果。结果:与VSE组相比,VRE在尿液标本中最多,以屎肠球菌最多,重症医学科中检出最多。比较VRE组与VSE组的药敏结果,多项抗生素药敏结果呈临界阳性(P≥0.1)。结论:万古霉素耐药肠球菌多从尿液标本中分离,且屎肠球菌最多,在重症医学科中常见。VRE组与VSE组对不同抗菌药物的耐药率及敏感率差别不大。Objective:To study the clinical characteristics and drug resistance of vancomycin-resistant enterococci infection patients in Tai’an.Method:Samples of hospitalized patients from January 2019 to December 2022 in Tai’an Hospital of Traditional Chinese Medicine were collected,including bacterial cultures of blood,urine,ascites,etc.,in a total of 335 cases.They were divided into two groups according to the results of drug sensitivity,including 37 cases in vancomycin-resistant enterococcus(VRE)group and 298 cases in vancomycin-sensitive enterococcus(VSE)group.According to the medical records,the clinical data of the patients were extracted,including gender,age,department,etc.The results of bacterial identification and drug sensitivity in the laboratory were collected.Result:Compared with the VSE group,VRE was the most common in urine samples,the most common in feces,and the most common in intensive care.The drug susceptibility results of VRE group and VSE group were compared,and the drug susceptibility results of multiple antibiotics were critically positive(P≥0.1).Conclusion:Vancomycin-resistant enterococcus were mostly isolated from urine samples,and Enterococcus faecium was the most,and common in intensive care medicine.There was no significant difference between VRE group and VSE group in drug resistance and sensitivity to different antibiotics.

关 键 词：肠球菌 抗生素 万古霉素 耐药性 

分 类 号：R446.5[医药卫生—诊断学]