滋肾育胎丸联合贝米肝素钠治疗肾虚血瘀型复发性流产的临床观察  

Clinical observation of Zishen Yutai pill combined with beimiheparin sodium in recurrent spontaneous abortion of kidney deficiency and blood stasis type

作　　者：郭晨[1] 万云慧 易迎春[1] 张晓玲[1] GUO Chen;WAN Yunhui;YI Yingchun;ZHANG Xiaoing(Department of Reproductive Health,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,Jiangxi,China)

机构地区：[1]江西省妇幼保健院生殖健康科,江西南昌330006

出　　处：《中国现代医生》2024年第21期104-107,共4页China Modern Doctor

基　　金：江西省中医药管理局科技计划项目(2023B0133)。

摘　　要：目的探讨滋肾育胎丸联合贝米肝素钠治疗肾虚血瘀型复发性流产(recurrent spontaneous abortion,RSA)的临床效果。方法选取2021年1月至2023年6月江西省妇幼保健院收治的98例肾虚血瘀型RSA患者,随机分为观察组和对照组,每组49例。对照组患者予贝米肝素钠治疗,观察组患者加用滋肾育胎丸治疗。比较两组患者的临床疗效、中医证候积分、性激素水平、子宫动脉血流参数、保胎情况及不良反应。结果治疗后观察组总有效率高于对照组(P<0.05);屡孕屡堕、腰骶酸痛、阴道流血、双膝酸软积分低于对照组(P<0.05);孕酮、人绒毛膜促性腺激素、雌二醇水平高于对照组(P<0.05);子宫动脉阻力指数、收缩期与舒张期流速比、脉搏动指数低于对照组(P<0.05);保胎成功率、活产率高于对照组(P<0.05);两组患者的不良反应比较,差异无统计学意义(P>0.05)。结论滋肾育胎丸联合贝米肝素钠可提高RSA患者的疗效,改善患者的性激素水平,利于保胎,提高最终活产率。Objective To explore the clinical effect of Zishen Yutai pill combined with beimiheparin sodium in the treatment of recurrent spontaneous abortion(RSA)of kidney deficiency and blood stasis type.Methods A total of 98 RSA patients with kidney deficiency and blood stasis type admitted to Jiangxi Maternal and Child Health Hospital from January 2021 to June 2023 were randomly divided into observation group and control group,49 cases in each group.The patients of control group were treated with beimiheparin sodium,while the patients of observation group were treated with Zishen Yutai pill.Compare the clinical efficacy,traditional Chinese medicine syndrome score,sex hormone levels,uterine artery blood flow parameters,fetal protection status,and adverse reactions between two groups.Results After treatment,the total effective rate of observation group was higher than that of control group(P<0.05);Observation group had lower rates of repeated pregnancies,falls,lumbosacral pain,vaginal bleeding,and knee soreness and softness scores than control group(P<0.05);The levels of progesterone,human chorionic gonadotropin,and estradiol in observation group were higher than those in control group(P<0.05);The uterine artery resistance index,systolic and diastolic flow velocity ratio,and pulse index in observation group were lower than those in control group(P<0.05);The success rate and live birth rate of observation group were higher than those of control group(P<0.05);There was no statistically significant difference in the adverse reactions between two groups of patients(P>0.05).Conclusion The combination of Zishen Yutai pill and beimiheparin sodium can improve the therapeutic effect of RSA patients,improve their sex hormone levels,facilitate fetal preservation,and increase the final live birth rate.

关 键 词：复发性流产 滋肾育胎丸 贝米肝素钠 性激素水平 中医证候积分 

分 类 号：R714.21[医药卫生—妇产科学]