类风湿关节炎的JAK/STAT信号通路文献计量分析研究  

Bibliometric analysis of JAK/STAT signaling pathway in rheumatoid arthritis

作　　者：苏小军[1] 朱文菊 包强[1] 王欢 何倩 马骏 王海东[1] 田雪梅[1] 马富海[1] 沈海丽[3] 杨会军 SU Xiaojun;ZHU Wenju;BAO Qiang;WANG Huan;HE Qian;MA Jun;WANG Haidong;TIAN Xuemei;MA Fuhai;SHEN Haili;YANG Huijun(Department of Rheumatology and Osteopathy,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu,China;College of Integrative Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730030,Gansu,China;Department of Rheumatology and Immunology,the Second Hospital of Lanzhou University,Lanzhou 730030,Gansu,China)

机构地区：[1]甘肃省中医院风湿骨病科,甘肃兰州730050 [2]甘肃中医药大学中西医结合学院,甘肃兰州730030 [3]兰州大学第二医院风湿免疫科,甘肃兰州730030

出　　处：《中国现代医生》2024年第20期1-4,8,共5页China Modern Doctor

基　　金：国家自然科学基金项目(82260880);甘肃省自然科学基金项目(22JR5RA626);甘肃省中医药管理局重点科研项目(GZKZ-2021-3)。

摘　　要：目的通过对近十年Janus激酶(Janus kinase,JAK)/信号转导和转录激活因子(signal transducer and activator of transcription,STAT)信号通路对类风湿关节炎作用的文献进行多软件可视化分析,总结该领域发展趋势和研究热点,为研究者提供新的方向和思路,促进该领域创新性发展。方法收集Web of Science Core Collection数据库2013至2023年JAK/STAT信号通路在类风湿关节炎中的相关文献。利用CiteSpace和VOSviewer软件对检索到的354篇文章的发文量、国家、作者、关键词进行分析。结果该领域发文量持续增加,根据作者研究方向、高频词的呈现及对前言和热点的关注,提示该领域聚焦于基因表达、免疫机制、炎症机制、途径抑制剂、药物治疗等。未来研究将围绕通路抑制剂、抗风湿药物的安全性、机制、对照试验等展开。结论JAK/STAT信号通路对类风湿关节炎影响的研究在过去、现在乃至未来关注度高,研究价值大。各团队对该领域的研究存在差异,区域发展不平衡,提示应加强合作与交流、聚焦国际前沿、开展更多高质量研究,以推动该领域的发展和进步,为临床提供依据。Objective Based on the multi-software visual analysis of the literature on the effect of Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway on rheumatoid arthritis in the past decade,the development trend and research hotspot in this field are summarized.To provide researchers with new directions and ideas to promote the innovative development of the field.Methods The literatures related to JAK/STAT signaling pathway in rheumatoid arthritis were collected from the Web of Science Core Collection database from 2013 to 2023.CiteSpace and VOSviewer software were used to analyze the number of publications,countries,authors and keywords of 354 articles retrieved.Results The number of published papers in this field continues to increase.According to the author's research direction,the presentation of high-frequency words,and the attention to the preface and hot topics,it is suggested that this field focuses on gene expression,immune mechanism,inflammatory mechanism,pathway inhibitors,drug therapy,etc.Future research will focus on the safety,mechanism and controlled trials of pathway inhibitors and antirheumatic drugs.Conclusion The effect of JAK/STAT signaling pathway on rheumatoid arthritis has attracted much attention in the past,present and future.There are differences in the research of different teams in this field,and the regional development is unbalanced,suggesting that we should strengthen cooperation and exchanges,focus on the international frontier,and carry out more high-quality research to promote the development and progress of this field,and provide clinical basis.

关 键 词：类风湿关节炎 JAK/STAT信号通路 CITESPACE VOSviewer 可视化 研究趋势 

分 类 号：R593.22[医药卫生—内科学]