桑菊饮加减治疗对风热犯肺型咳嗽变异性哮喘患者气道功能 诱导痰指标及炎症因子的影响  

Effects of modified Sangjuyin Decoction on airway function,induced sputum indicators and inflammatory factors in cough variant asthma with wind-heat invading lung syndrome

作　　者：宣方杰 何小军 Xuan Fangjie;He Xiaojun(Department of Emergency,General Hospital of Traditional Chinese Medicine,Keqiao District Hospital,Shaoxing City,Shaoxin,Zhejiang 312030,China)

机构地区：[1]浙江省绍兴市柯桥区中医医院医共体总院急诊科,浙江绍兴312030

出　　处：《中国药物与临床》2024年第13期833-836,共4页Chinese Remedies & Clinics

摘　　要：目的探究桑菊饮加减治疗对风热犯肺型咳嗽变异性哮喘患者气道功能、诱导痰指标及炎症因子的影响。方法选择2020年5月至2022年5月在浙江省绍兴市柯桥区中医医院医共体总院治疗的咳嗽变异性风热犯肺型哮喘患者127例,按随机数字表法分为观察组(64例)和对照组(63例),对照组仅给予西医基础治疗,观察组患者给予西医基础治疗加桑菊饮治疗,对比2组患者临床疗效和治疗前后的中医证候积分,日间、夜间咳嗽症状评分,气道功能,诱导痰指标及炎症因子水平。结果治疗后,观察组总有效率为95%,高于对照组84%(P<0.05);2组患者中医证候积分及日间、夜间咳嗽评分均降低,且观察组均低于对照组(P<0.05);2组患者嗜酸性粒细胞(EOS)水平、血清炎症因子[白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平均降低,且观察组均低于对照组(P<0.05);2组患者气道功能指标[肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大呼气中段流速(MMEF)]均升高,且观察组均高于对照组(P<0.05);观察组患者的复发率低于对照组(P<0.05);2组无不良反应发生。结论桑菊饮加减治疗可有效改善风热犯肺型咳嗽变异性哮喘患者气道功能,降低诱导痰指标及血清炎性因子水平,并且可以降低复发率,安全性良好,疗效显著。Objective To investigate the effect of modified Sangjuyin decoction on airway function,induced sputum indicators,and inflammatory factors in cough variant asthma with wind-heat invading lung syndrome.Methods A total of 127 patients with cough variant asthma of wind-heat invading lung syndrome treated in our hospital from May 2020 to May 2022 were selected and randomly divided into an observation group(n=64)and control group(n=63).The control group was given only basic Western medicine treatment,while the observation group were given basic Western treatment plus Sangjuyin decoction.The clinical efficacy,TCM syndrome scores before and after treatment,daytime and nighttime cough symptom scores,airway function,induced sputum indicators,and inflammatory factor levels were compared between the two groups.Results After treatment,the total effective rate of the observation group was 95%,significantly higher than that of the control group(84%,P<0.05).The scores of TCM syndromes and daytime and nighttime cough cores in both groups decreased,and the observation group was lower than the control group(P<0.05).The levels of eosinophil(EOS),serum inflammatory factors[interleukin-4(IL-4),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)]in both groups decreased,and the observation group was lower than the control group(P<0.05).The airway function indicators[vital capacity(FVC),forced expiratory volume in the first second(FEV1)and maximal mid-expiratory flow(MMEF)]in both groups increased,and the observation group was higher than the control group(P<0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05).No significant adverse reactions occurred in the observation group.Conclusion Sangjuyin modified therapy can effectively improve the airway function of patients with cough variant asthma caused by wind-heat invading lung,reduces induced sputum inflammatory indexes,and serum inflammatory factor levels,and can also reduce the recurrence rate with good safety and significant efficacy

关 键 词：桑菊饮 哮喘 气道功能 痰 炎症因子 

分 类 号：R256.1[医药卫生—中医内科学]