肠道菌群与肌肉减少症患者骨骼肌蛋白质代谢的研究进展  

Gut microbiota and skeletal muscle protein metabolism in sarcopenia:research progress

作　　者：向青[1] 胡悦 柳维林[1] XIANG Qing;HU Yue;LIU Weilin(*Institute of Rehabilitation Industry,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China;不详)

机构地区：[1]福建中医药大学康复产业研究院,福建福州350122 [2]福建中医药大学康复医学院

出　　处：《中国微生态学杂志》2024年第6期742-744,F0003,共4页Chinese Journal of Microecology

基　　金：福建省自然科学基金面上项目(2023J01888);福建中医药大学基础类学科科研提升计划项目(XJC2022005)。

摘　　要：近年来的研究认为肠道菌群可影响骨骼肌的质量和功能,并提出了“肠-肌轴”理论。随着世界人口老龄化的日趋严重,肌肉减少症越来越受到人们的关注,成为严重损害老年人健康的疾病之一。临床研究发现,肌肉减少症患者肠道菌群的多样性降低,有益菌显著减少,有害菌大量增加。调节肠道菌群可改善肌肉减少症患者的骨骼肌质量和功能。肠道菌群代谢产物,如氨基酸、脂多糖和短链脂肪酸等对骨骼肌蛋白质的代谢具有调控作用,通过多种途径调节骨骼肌蛋白质的合成与分解。因此,本文对肌肉减少症患者肠道菌群的变化及其代谢产物对骨骼肌蛋白质的调控作用进行综述,以期为肌肉减少症的临床治疗提供新的思路。Recent studies have suggested that gut microbiota can affect the mass and function of skeletal muscle,and proposed the theory of"gut-muscle axis".With the increasing aging of the world's population,sarcopenia is getting more and more attention and becoming one of the diseases that seriously damage the health of the elderlies.Clinical studies have found that the diversity of gut microbiota in sarcopenia reduced,with a significant decrease in beneficial bacteria and an increase in harmful bacteria.Regulating gut microbiota can improve the mass and function of skeletal muscle in sarcopenia.The metabolites of gut microbiota,such as amino acids,lipopolysaccharides and short-chain fatty acids,have regulatory effects on skeletal muscle protein metabolism,and regulate skeletal muscle protein synthesis and catabolism through various pathways.Therefore,this paper reviews the changes in the gut microbiota in sarcopenia and the regulatory role of its metabolites on skeletal muscle protein metabolism,in order to provide new strategies for the clinical treatment of sarcopenia.

关 键 词：肌肉减少症 肠道菌群 骨骼肌 蛋白质代谢 

分 类 号：R592[医药卫生—老年医学]