中国儿童2型炎症型哮喘单核苷酸多态性和相关基因关系的研究进展  

Single nucleotide polymorphisms and related genes in Chinese children with type 2 inflammatory asthma

作　　者：苏醒岳 王蓓蕾 马香[1] Su XingYue;Wang Beilei;Ma Xiang(Children’s Hospital Affiliated to Shandong University,Ji’nan 250022,China)

机构地区：[1]山东大学附属儿童医院,济南250022

出　　处：《结核与肺部疾病杂志》2024年第4期370-375,共6页Journal of Tuberculosis and Lung Disease

摘　　要：支气管哮喘是严重影响儿童身心健康的一种慢性炎症性疾病,根据炎症机制与表现的不同,分为2型炎症型哮喘及非2型炎症型哮喘。2型炎症型哮喘患儿数量多、占比大、症状重、疗效差。哮喘的发病机制复杂,其中遗传变异在哮喘的发生和发展中发挥着至关重要的作用,通过基因学研究设置诊断模型及个体化治疗方案具有重要意义。作者系统地回顾目前2型炎症型哮喘相关基因区域及单核苷酸多态性的研究,以更好地了解遗传因素与哮喘发生和发展之间的关系,为未来的哮喘预测诊断模型及个体化治疗方案制定提供依据。Bronchial asthma is a chronic inflammatory disease that significantly impacts the physical and mental health of children.It is classified into type 2 inflammatory asthma and non-type 2 inflammatory asthma based on distinct mechanisms and manifestations of inflammation.Type 2 inflammatory asthma represents a substantial proportion of pediatric asthma cases,characterized by severe symptoms and poor clinical outcomes.The pathogenesis of asthma is complex,with genetic variation playing a critical role in its onset and progression.Developing diagnostic models and individualized treatment plans from a genetic perspective is therefore of paramount importance.The authors systematically summarizes current research on gene regions and single nucleotide polymorphisms associated with type 2 asthma,aiming to elucidate the relationship between genetic factors and the development of asthma,and to provide a foundation for future predictive diagnostic models and individualized treatment strategies for asthma.

关 键 词：哮喘 多态性 单核苷酸 儿童 基因 

分 类 号：R256.12[医药卫生—中医内科学]