同轴静电纺抗菌PLA纳米纤维膜的制备及其性能  

Preparation and property of coaxial electrospinning antibacterial PLA nanofiber membrane

作　　者：张菂 刘淑强[1] 武捷[1] 李静静 李甫 ZHANG Di;LIU Shuqiang;WU Jie;LI Jingjing;LI Fu(Taiyuan University of Technology,Taiyuan 030024,China)

机构地区：[1]太原理工大学,山西太原030024

出　　处：《棉纺织技术》2024年第8期8-12,共5页Cotton Textile Technology

基　　金：山西省科技成果转化引导专项项目(202104021301053);山西省基础研究计划项目(20210302123114,202203021211146);山西省高等学校科技成果转化培育项目(2020CG014);山西省重点研发计划项目(202302040201009);山西省社科联2021年度重点课题(SSKLZDKT2021025)。

摘　　要：为了获得释药速率稳定的载药纳米纤维膜,以聚乳酸(PLA)为原料,采用同轴静电纺工艺制备具有皮芯结构的纳米纤维膜。分析了皮层与芯层不同推注速度比下制备的静电纺纳米纤维膜的化学结构、亲水性能、抗菌性能、药物缓释性能。结果表明:复合抗菌剂Ag@TP粒子分布均匀且较为纯净,并能够成功复合到静电纺纳米纤维膜上。当皮层与芯层推注速度比为3∶1时,制得的纳米纤维具有较为均匀的直径分布,并且纤维因其粗糙的表面而具有更大的比表面积,使得相同条件下的纤维膜能够吸附更多细菌,同时疏水性较强且断裂伸长率达到最大。认为:与共混结构的纳米纤维膜相比,具有皮芯结构的同轴静电纺纳米纤维膜可以有效缓解突释问题,能够更好地实现抗菌剂的长效稳定释放。In order to obtain drug-releasing nanofiber membranes with stable release rates,polylactic acid(PLA)was used as the raw material.The nanofiber membranes with a core-sheath structure were prepared using the coaxial electrospinning process.The chemical structure,hydrophilic performance,antibacterial property and medicine slow release property of electrospun nanofiber membranes prepared with different injection speeds for surface layer and core layer were analyzed.Results showed that the composite antibacterial agent Ag@TP had a uniform distribution and high purity,and it could be successfully incorporated into the electrospun nanofiber membranes.When the injection velocity ratio of surface layer and core layer was 3∶1,the diameter distribution of the prepared nanofiber was more uniform.The nanofiber had a larger specific surface area due to rough surface,which could adsorb more bacteria on the fiber membrane for the same condition.Meanwhile,its hydrophobic property was strong and the breaking elongation was reached to the maximum.It is considered that the coaxial electrospun nanofiber membrane with the surface core structure can effectively alleviate the problem of burst release issues compared with the blended structure nanofiber membrane.It can better achieve sustained release of the antibacterial agent.

关 键 词：聚乳酸 纳米纤维膜 同轴静电纺 载药 抗菌性能 缓释 

分 类 号：TS171[轻工技术与工程—纺织材料与纺织品设计]