从“脾藏营舍意”论溃疡性结肠炎诱发抑郁的机制  

Discussion on Mechanism of Depression Induced by Ulcerative Colitis from Perspective of“Spleen Storing Nutrient and Housing Idea”

作　　者：刘薇[1] 田锋亮[1] 曾健 袁玲 刘宇[1] 邱红[1] 路琼琼 徐健众(指导)[1] LIU Wei;TIAN Fengliang;ZENG Jian;YUAN Ling;LIU Yu;QIU Hong;LU Qiongqiong;XU Jianzhong(Mentor)(Chongqing Traditional Chinese Medicine Hospital,Chongqing 400013,China)

机构地区：[1]重庆市中医院,重庆400013

出　　处：《山东中医杂志》2024年第8期824-828,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金项目(编号:82205085);中国博士后科学基金面上项目(编号:2023M740437);重庆市自然科学基金博士后项目(编号:2022NSCQ-BHX4879);重庆市博士后研究项目特别资助二等资助(编号:2023CQBSHTB2042);重庆市科研机构绩效激励引导专项(编号:jxyn2021-1-12);四川省科技厅区域创新合作项目(编号:2023YFQ0016)。

摘　　要：“脾藏营舍意”首见于《灵枢·本神》,体现了脾运化水谷精微上输于脑以滋养“意”的功能。若是脾的功能受到损害,“意”的功能也将无法正常发挥。该病理理念与溃疡性结肠炎诱发抑郁的病理机制——肠道炎性反应中枢侵袭及其他一系列病理反应导致大脑海马损伤最终诱发抑郁行为的病理过程相合。阐释中医“脾藏营舍意”理论与溃疡性结肠炎诱发抑郁机制的相关性,以期将“脾藏营舍意”这一理论用于指导溃疡性结肠炎诱发抑郁的临床诊疗。“Spleen storing nutrient and housing idea”is initially recorded in Miraculous Pivot·Roots of Spirit,which reflects the function of spleen in transporting and transforming the essence of water and grains to the brain to nourish the“idea”.If the function of the spleen is damaged,the function of“idea”will not be able to exert.The concept of this pathology is consistent with the pathological mechanism of ulcerative colitis-induced depression——the intestinal inflammatory response invades the central nervous system and other series of pathological reactions lead to damage to the brain hippocampus and ultimately induce depressive-like behavior.This paper elucidates the correlation between the traditional Chinese medicine theory of“spleen storing nutrient and housing idea”and the mechanism of depression induced by ulcerative colitis,with a prospect of applying the theory of“spleen storing nutrient and housing idea”in guiding the clinical diagnosis and treatment of depression induced by ulcerative colitis.

关 键 词：溃疡性结肠炎 抑郁 脾藏营舍意 临床诊疗 

分 类 号：R259.746.2[医药卫生—中西医结合]