补肾疏肝散结汤治疗乳腺增生病及对血清性激素水平的影响  

Effect of Bushen Shugan Sanjie Decoction(补肾疏肝散结汤)on Breast Hyperplasia and Serum Sex Hormone Level

作　　者：郑昳 钱丽旗[1] 黄雪 陈晓娜 于洋[1] ZHENG Yi;QIAN Liqi;HUANG Xue;CHEN Xiaona;YU Yang(Department of Traditional Chinese Medicine,PLA General Hospital,Beijing 100048,China;Beijing North Medical District,PLA General Hospital,Beijing 100094,China)

机构地区：[1]解放军总医院中医医学部,北京100048 [2]解放军总医院京北医疗区,北京100094

出　　处：《山东中医杂志》2024年第8期847-852,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：中国医药教育协会孙思邈中医药科研专项课题(编号:协字[2016]038号)。

摘　　要：目的:探讨补肾疏肝散结汤治疗乳腺增生病的疗效及对血清性激素水平的影响。方法:研究对象为2020年7月至2022年8月就诊的乳腺增生病患者90例。随机分成两组各45例。对照组予枸橼酸他莫昔芬片治疗,观察组联合补肾疏肝散结汤治疗,均连续治疗3个月经周期。观察两组治疗前后中医证候积分(乳腺包块、乳腺疼痛、乳头溢液、其他伴随症状)、乳腺超声指标、血清性激素[孕酮(P)、泌乳素(PRL)、雌二醇(E_(2))]水平、治疗后3个月和6个月疾病复发率,并比较两组临床总有效率和安全性。结果:两组治疗后中医证候积分、乳腺超声指标、PRL、E_(2)水平均水平均降低(P<0.05),且观察组较对照组低(P<0.05);两组P水平均升高(P<0.05),且观察组较对照组高(P<0.05);观察组同期复发率均较对照组低(P<0.05);观察组总有效率较对照组高(P<0.05);组间不良反应发生率比较差异无统计学意义(P>0.05)。结论:补肾疏肝散结汤治疗乳腺增生病效果显著,能够有效缓解乳腺疼痛等不适症状,调节血清性激素水平,改善乳腺超声指标,降低疾病复发率,且不良反应较少。Objective:To investigate the curative effect of Bushen Shugan Sanjie Decoction(补肾疏肝散结汤)on patients with breast hyperplasia and its effect on serum sex hormone level.Methods:The study subjects were 90 patients with breast hyperplasia who were diagnosed and treated from July 2020 to August 2022.And they are randomly divided into two groups of 45 cases each.The control group was treated with tamoxifen citrate tablets,and the observation group was treated with Bushen Shugan Sanjie Decoction for 3 consecutive menstrual cycles.Traditional Chinese medicine(TCM)syndrome score(breast mass,breast pain,nipple discharge,and other accompanying symptoms),breast ultrasound index,serum sex hormone[progesterone(P),prolactin(PRL),estradiol(E_(2))]levels,and disease recurrence rate at 3 and 6 months after treatment were observed in the two groups before and after treatment,and the total clinical effective rate and treatment safety were compared between the two groups.Results:After treatment,TCM syndrome score,breast ultrasound indicators,PRL and E_(2) levels were all decreased in both groups(P<0.05),and the observation group was lower than the control group(P<0.05).The P indexes of both groups were increased(P<0.05),and the observation group was higher than the control group(P<0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusions:Bushen Shugan Sanjie Decoction has a significant effect in the treatment of breast hyperplasia,which can effectively relieve breast pain and other discomfort symptoms,regulate serum sex hormone levels,improve breast ultrasound indicators,reduce the recurrence rate of disease,and have fewer adverse reactions.

关 键 词：乳腺增生 补肾疏肝散结汤 性激素 乳腺超声指标 肝郁肾虚证 复发率 

分 类 号：R271.44[医药卫生—中医妇科学]