Damage on intestinal barrier function and microbial detoxification of deoxynivalenol:A review  

作　　者：Jia Chen Xinran Zhang Ziqi He Dongwei Xiong Miao Long 

机构地区：[1]Key Laboratory of Livestock Infectious Diseases,Ministry of Education/College of Animal Science and Veterinary Medicine, ShenyangAgricultural University,Shenyang 110866,China

出　　处：《Journal of Integrative Agriculture》2024年第8期2507-2524,共18页农业科学学报（英文版）

基　　金：funded by the National Natural Science Foundation of China(32273074,31972746,31872538 and 31772809);the Basic Scientific Research Project of Liaoning Provincial Department of Education,China(LJKZ0632)。

摘　　要：Deoxynivalenol(DON)is a mycotoxin that is produced by various species of Fusarium and is ubiquitous in food and feed.At low concentrations,it can cause metabolic disorders in animals and humans and,at high concentrations,it can lead to pathological changes in the body.The impact of DON on human/animal health and animal productivity has thus attracted a great deal of attention around the world.DON causes severe damage to the intestine,including compromised intestinal barrier,mucosal damage,weakened immune function,and alterations in gut microbiota composition.These effects exacerbate intestinal infections and inflammation in livestock and poultry,posing adverse effects on overall health.Furthermore,research into biological methods for DON detoxification is a crucial avenue for future studies.This includes the utilization of adsorption,enzymatic degradation,and other biological approaches to mitigate DON's impact,offering new strategies for prevention and treatment of DON-induced diseases.Future research will focus on identifying highly efficient detoxifying microorganisms or enzymes to reduce DON levels in food and feed,thereby mitigating its risks to both animals and human health.

关 键 词：deoxynivalenol(DON) intestinal barrier function mucus barrier immune function flora composition biological detoxification 

分 类 号：S859.8[农业科学—临床兽医学]