儿童过敏性紫癜的营养状况和25-羟基维生素D_(3)水平的临床研究  

Analysis of nutritional status and signifi cance of changes in 25-hydroxyvitamin D_(3)levels in children with Henoch-Schönlein purpura

作　　者：潘长鹭 王美辰 赵文利[1] 栗达[1] 闫洁[1] Pan Changlu;Wang Meichen;Zhao Wenli;Li Da;Yan Jie(Department of Clinical Nutrition,Beijing Children’s Hospital,Capital Medical University,National Children’s Medical Center,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院临床营养科,北京100045

出　　处：《中国医刊》2024年第8期879-881,共3页Chinese Journal of Medicine

摘　　要：目的探讨不同营养状况及血清25-羟基维生素D_(3)[25-(OH)D_(3)]水平与儿童过敏性紫癜(HSP)的相关性。方法选取2019年9月至2020年2月于首都医科大学附属北京儿童医院确诊的HSP患儿共119例作为观察组,根据营养状况进一步分为营养正常组(67例)与营养不良组(52例),同时选取同时期于首都医科大学附属北京儿童医院门诊进行健康体检的儿童90例作为对照组。比较分析观察组和对照组、营养正常组和营养不良组儿童的25-(OH)D_(3)水平。结果对照组儿童的25-(OH)D_(3)水平显著高于观察组患儿,差异有统计学意义(P<0.05);营养不良组患儿的25-(OH)D_(3)水平低于营养正常组,差异有统计学意义(P<0.05)。结论HSP患儿25-(OH)D_(3)水平与健康儿童相比明显降低,HSP合并营养不良患儿的25-(OH)D_(3)水平与营养状态正常的HSP患儿相比明显降低。Objective To investigate the relationship between different nutritional status and serum 25-hydroxyvitamin D_(3)[25-(OH)D_(3)]level and children’s Henoch-Schönlein purpura(HSP).Method A total of 119 children with HSP diagnosed in Beijing Children’s Hospital,Capital Medical University from September 2019 to February 2020 were selected as the observation group,and further divided into normal nutrition group(67 cases)and malnutrition group(52 cases)according to their nutritional status.Meanwhile,90 children who underwent physical examination in the outpatient department of Beijing Children’s Hospital,Capital Medical University were selected as the control group.The 25-(OH)D_(3)levels of children in observation group and control group,normal nutrition group and malnourished group were compared and analyzed.Result The level of 25-(OH)D_(3)in control group was signifi cantly higher than that in observation group,and the difference was statistically signifi cant(P<0.05).The level of 25-(OH)D_(3)in malnutrition group was lower than that in normal nutrition group,and the difference was statistically signifi cant(P<0.05).Conclusion The levels of 25-(OH)D_(3)in children with HSP were signifi cantly lower than those in the healthy children group;the levels of 25-(OH)D_(3)in the HSP combined with malnutrition group were signifi cantly lower than those in the HSP group with normal nutritional status.

关 键 词：25-羟基维生素D_(3) 过敏性紫癜 营养不良 

分 类 号：R725[医药卫生—儿科]