可溶性血管细胞黏附分子-1、中性粒细胞与淋巴细胞比值在过敏性紫癜患儿血清中的变化及检测意义  

Changes of soluble vascular cell adhesion molecule-1 and neutrophil-to-lymphocyte ratio in the serum of children with Henoch-Sch nlein purpura and their significance

作　　者：王爱琳 潘靓 张金秀 刘冬阳 唐文秀 席阳 王丽 WANG Ailin;PAN Liang;ZHANG Jinxiu;LIU Dongyang;TANG Wenxiu;XI Yang;WANG Li(Department of Pediatrics,the General Hospital of Western Theater Command,Chengdu 610083,China)

机构地区：[1]西部战区总医院儿科,四川成都610083

出　　处：《陕西医学杂志》2024年第8期1073-1076,共4页Shaanxi Medical Journal

基　　金：四川省卫生健康科研课题普及项目(19PJ286)。

摘　　要：目的:探讨可溶性血管细胞黏附分子-1(sVCAM-1)、中性粒细胞与淋巴细胞比值(NLR)在过敏性紫癜(HSP)患儿血清中的变化及检测意义。方法:选取接受诊治的HSP患儿86例(HSP组),另选取同时期体检健康儿童101例(对照组)。检测中性粒细胞、淋巴细胞及血清sVCAM-1,计算NLR。比较对照组和HSP组NLR、sVCAM-1水平变化。比较HSP组不同疾病分期患儿NLR、sVCAM-1水平变化。随访6个月,根据肾脏病变或复发情况将患儿分为预后不良组(14例)和预后良好组(72例)。比较HSP组不同预后患儿NLR与sVCAM-1水平变化,分析NLR与sVCAM-1水平对HSP患儿预后不良的预测价值。采用Pearson法分析HSP组NLR与sVCAM-1水平的相关性。结果:与对照组比较,HSP患儿NLR、sVCAM-1水平更高(均P<0.05)。在HSP组中,急性期患儿NLR、sVCAM-1水平高于恢复期患儿(均P<0.05)。预后不良组NLR、sVCAM-1水平高于预后良好组(均P<0.05)。NLR联合sVCAM-1预测患儿预后不良的AUC为0.712,高于NLR与sVCAM-1单独预测的AUC(均P<0.05)。NLR与sVCAM-1水平呈正相关(P<0.05)。结论:HSP患儿sVCAM-1和NLR水平升高,与病情活动性和预后有关,两者联合对患儿预后预测具有一定价值。Objective:To investigate the changes of soluble vascular cell adhesion molecule-1(sVCAM-1)and neutrophil-to-lymphocyte ratio(NLR)in the serum of children with Henoch-Sch nlein purpura(HSP)and their significance.Methods:A total of 86 children with HSP(HSP group)and 101 healthy children(control group)were selected.Neutrophils,lymphocytes and serum sVCAM-1 were detected and NLR was calculated.The levels of NLR and sVCAM-1 in control group and HSP group were compared.The levels of NLR and sVCAM-1 in children with different disease stages in HSP group were compared.The patients were followed up for 6 months and divided into poor prognosis group(14 cases)and good prognosis group(72 cases)according to kidney lesions or recurrence.The levels of NLR and sVCAM-1 in children with different prognosis in HSP group were compared,and the value of NLR and sVCAM-1 levels in predicting poor prognosis of children with HSP was analyzed.The correlation between NLR and sVCAM-1 levels in HSP group was analyzed by Pearson method.Results:Compared with the control group,the levels of NLR and sVCAM-1 were higher in the HSP group(all P<0.05).In the HSP group,the levels of NLR and sVCAM-1 in the acute stage were higher than those in the convalescent stage(all P<0.05).The levels of NLR and sVCAM-1 in the poor prognosis group were higher than those in the good prognosis group(all P<0.05).The AUC of NLR combined with sVCAM-1 in predicting poor prognosis was 0.712,which was higher than that of NLR and sVCAM-1 alone(all P<0.05).NLR was positively correlated with sVCAM-1 level(P<0.05).Conclusion:The levels of sVCAM-1 and NLR are increased in children with HSP,which are related to the disease activity and prognosis,and the combination of the two has certain value in predicting the prognosis of children.

关 键 词：过敏性紫癜 中性粒细胞与淋巴细胞比值 可溶性血管细胞黏附分子-1 病情活动性 预后 预测价值 

分 类 号：R554.6[医药卫生—血液循环系统疾病]