长链非编码RNA在脓毒症相关器官损伤中的作用研究进展  

Research progress on the role of long non-coding RNAs in sepsis-related organ injury

作　　者：张光锐  董良杰 王睿 柴瑞峰[1] ZHANG Guangrui;ORASH Boqiev;DONG Liangjie;WANG Rui;CHAI Ruifeng(Department of Intensive Care Unit,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院重症医学科,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院,新疆乌鲁木齐830054

出　　处：《陕西医学杂志》2024年第8期1145-1149,共5页Shaanxi Medical Journal

基　　金：新疆维吾尔自治区自然科学基金资助项目(2020D01C233)。

摘　　要：长链非编码RNA(lncRNA)广泛参与生物体内各种重要的生理过程。越来越多的证据表明,lncRNA对脓毒症的病理生理学和器官功能障碍具有关键的调节作用,主要通过参与炎症反应以及在各种信号通路中发挥效能。脓毒症是炎症反应引起的生理、病理和生化异常综合征。但目前脓毒症的发病机制还未完全了解,许多研究证明lncRNA与脓毒症关系密切。因此,现就部分lncRNA在脓毒症相关器官损伤中的作用及可能机制进行综述。Long non-coding RNAs(lncRNAs)are widely involved in various important physiological processes in vivo.More and more evidence has shown that lncRNAs play a key regulatory role in the pathophysiology and organ dysfunction of sepsis,mainly through participating in inflammatory response and exerting their efficacy in various signaling pathways.Sepsis is a syndrome of physiological,pathological and biochemical abnormalities caused by inflammation.However,the pathogenesis of sepsis is still not fully understood,and many studies have proved that lncRNA is closely related to sepsis.Therefore,this article reviews the roles and possible mechanisms of some lncRNAs in sepsis-related organ injury.

关 键 词：脓毒症 长链非编码RNA 急性肺损伤 心肌功能障碍 脑功能障碍 急性肾损伤 急性肝损伤 急性肠损伤 

分 类 号：R631[医药卫生—外科学]