丹灯通脑软胶囊及其组方化学成分与分析方法研究进展  

Research progress on chemical composition and analysis methods of Dandeng Tongnao Soft Capsules and herbal medicines

作　　者：吴文玉 陈浩 焦欣 詹少锋[1,2] WU Wenyu;CHEN Hao;JIAO Xin;ZHAN Shaofeng(College of First Clinical Medical,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250300,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405 [3]山东中医药大学中医学院,山东济南250300

出　　处：《药学研究》2024年第7期677-683,共7页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81973814);广东省普通高校重点领域专项项目(No.2022ZDZX2014);广东省研究生教育创新计划项目(No.2022ANLK025);广东省中医药科研项目(No.20231169)。

摘　　要：丹灯通脑软胶囊源于彝医验方,由丹参、灯盏细辛、川芎、粉葛4味药物组成,具有活血化瘀、祛风通络等功效,临床上多用于冠心病、脑中风、高血压、心绞痛等疾病的治疗。复方的组成药物中以黄酮类、醌类、有机酸类等化学成分为主,研究证实该药具有扩张周围毛细血管、促进心脑血管循环、增加冠状动脉血流量和缓解心肌缺血的功效,本文通过回顾近年来的相关文献,对丹灯通脑软胶囊的化学组成成分、质量控制和体内代谢研究方法进行总结,旨在为丹灯通脑软胶囊及相关组方的药效物质基础的研究提供参考依据。Dandeng Tongnao Soft Capsules is originated from Yi Medicine prescription,composed of four medicines:Salvia,Erigeron breviscapus,Chuanxiong Rhizome,Kudzu,with the effects of activating blood circulation,removing wind and clearing collaterals,and is mostly used in the treatment of coronary heart disease,stroke,hypertension,angina pectoris,and other diseases in the clinic.The composition of the formula is mainly composed of flavonoids,quinones,organic acids and other chemical components,research has confirmed that the drug has the effect of expanding peripheral capillaries,promoting cardiovascular circulation,increasing coronary blood flow and alleviating myocardial ischemia.This paper summarized the chemical composition,quality control and in vivo metabolism of Dandeng Tongnao Soft Capsules by reviewing the relevant literature in recent years,aiming to provide a reference basis for the study of the pharmacological material basis of Dandeng Tongnao Soft Capsules and related formulas.

关 键 词：丹灯通脑软胶囊 化学成分 质量控制 体内代谢 丹参 灯盏细辛 川芎 粉葛 

分 类 号：R286[医药卫生—中药学]