药物经皮渗透性研究方法进展  

Advances in methods for the study of percutaneous permeability of drugs

作　　者：曹玉伟 王文心 杨书娟 郑静 徐玉文 CAO Yuwei;WANG Wenxin;YANG Shujuan;ZHENG Jing;XU Yuwen(School of Pharmaceutical Sciences,Shandong Universitiy,Jinan 250012,China;Shandong Institute for Food and Drug Control,Jinan 250101,China)

机构地区：[1]山东大学药学院,山东济南250012 [2]山东省食品药品检验研究院,山东济南250101

出　　处：《药学研究》2024年第7期689-693,共5页Journal of Pharmaceutical Research

基　　金：泰山产业领军人才项目(No.tscx202306073)。

摘　　要：经皮给药系统中药物的经皮渗透特性直接关系到药物临床应用的安全性和有效性。在经皮给药制剂的开发过程中,药物渗透性评估可以预测药物的皮肤渗透特性,有助于理解产品的质量和性能,为药品研发提供重要考察指标。目前,研究者们开发了多种药物皮肤渗透性研究方法,其中体外透皮试验最为常用,主流测定方法是Franz扩散池法;数学模型渗透性预测、动物实验等研究方法也可被用来研究药物渗透性,此外还有平行人工膜渗透模型研究、光谱技术及微透析技术等新的研究方法。本文对这些研究方法进行展开介绍,期望对研究者提供一定的参考作用。The percutaneous permeability of drugs in the transdermal drug delivery system is directly related to the safety and effectiveness of drugs in clinical application.In the development process of transdermal preparation,drug permeability evaluation can predict the skin permeability properties of drugs,help to understand product quality and performance,and provide an important indicator for drug development.At present,researchers have developed a variety of drug skin permeability research methods,in vitro transdermal test is the most commonly used,the mainstream method is Franz diffusion cell method;mathematical model permeability prediction,animal test and other research methods can also be used to study drug permeability,in addition to parallel artificial membrane permeability model research,spectral technology and microdialysis technology and other new methods.This paper introduces these research methods and hopes to provide some reference for researchers.

关 键 词：经皮给药系统 透皮试验 FRANZ扩散池 数学模型 微透析 

分 类 号：R943[医药卫生—药剂学]