点阵CO_(2)激光联合PRP治疗面部外伤缝合后瘢痕临床观察  

Clinical Observation of Fractional CO_(2) Laser Combined with PRP in the Treatment of Scars after Suture of Facial Trauma

作　　者：侯智慧[1] 高翔[2] 谷明娟[2] HOU Zhihui;GAO Xiang;GU Mingjuan(Department of Burn,Inner Mongolia Baogang Hospital,Baotou 014010,Inner Mongolia,China;Department of Plastic Surgery,Inner Mongolia Baogang Hospital,Baotou 014010,Inner Mongolia,China)

机构地区：[1]内蒙古包钢医院烧伤科,内蒙古包头014010 [2]内蒙古包钢医院整形外科,内蒙古包头014010

出　　处：《中国美容医学》2024年第8期38-42,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究点阵CO_(2)激光联合富血小板血浆(Platelet-rich plasma,PRP)治疗面部外伤缝合后瘢痕的效果。方法:选择2020年3月-2022年3月笔者医院收治的152例面部外伤患者,按随机数字表法分为激光组50例、PRP组51例和联合组51例。激光组采用超脉冲CO_(2)点阵激光治疗,PRP组采用PRP微针注射治疗,联合组采用点阵CO_(2)激光联合PRP治疗,比较三组患者疗效、炎性因子水平、创面处与正常皮肤厚度差、温哥华瘢痕量表(Vancouver scar scale,VSS)评分。结果:治疗6个月后,联合组总有效率高于PRP组、激光组(P<0.05)。与治疗前比较,治疗3个月、6个月、1年后三组患者瘢痕与正常皮肤厚度差逐渐下降,联合组创面处与正常皮肤厚度差均小于PRP组、激光组(P<0.05),PRP组创面处与正常皮肤厚度差均小于激光组(P<0.05)。与治疗前比较,治疗3个月、6个月、1年后三组VSS评分下降,联合组VSS评分均低于PRP组、激光组(P<0.05),PRP组VSS评分均低于激光组(P<0.05)。治疗6个月后,三组肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)、白细胞介素2(Interleukin-2,IL-2)、白细胞介素6(Interleukin-6,IL-6)均有不同程度下降,联合组炎性因子水平低于PRP组、激光组(P<0.05),PRP组炎性因子水平低于激光组(P<0.05)。结论:应用点阵CO_(2)激光联合PRP治疗面部外伤缝合患者,防治瘢痕疗效显著,炎症水平降低,瘢痕颜色、厚度、质地均明显改善。Objective To explore the effect of using fractional CO_(2) laser combined with platelet-rich plasma(PRP)in the treatment of scar after sutured facial trauma.Methods A total of 152 patients who underwent scar prevention treatment after plastic surgery and suture for facial trauma from March 2020 to March 2022 were selected.They were randomly divided into the laser group(50 cases),the PRP group(51 cases)and the combination group(51 cases).The laser group was treated with fractional CO_(2) laser.The PRP group was treated with PRP microneedle injection.The combination group was treated with fractional CO_(2) laser combined with PRP.Therapeutic effects,inflammatory factor levels,the difference in thickness between wound skin and normal skin,and Vancouver scar scale(VSS)scores were compared among the three groups.Results After 6 months of treatment,the total effective rate in the combination group was higher than those in the PRP group and the laser group(P<0.05).Compared with before treatment,the thickness of scars and normal skin in the three groups after 3 months,6 months and 1 year of treatment decreased gradually,the difference in thickness between wound skin and normal skin in the combination group was smaller than that in the PRP group and the laser group(P<0.05).Meanwhile,the difference in thickness between wound skin and normal skin in the PRP group was smaller than that in the laser group(P<0.05).Compared with before treatment,VSS scores of the three groups after 3 months,6 months and 1 year of treatment decreased gradually.VSS scores of the combination group were lower than those of the PRP group and the laser group(P<0.05),and VSS scores of the PRP group were lower than those of the laser group(P<0.05).After 6 months of treatment,the levels of tumor necrosis factor alpha(TNF-α),interleukin-2(IL-2)and interleukin-6(IL-6)in all groups decreased.The levels of inflammatory factors in the combination group were lower than those in the PRP group and the laser group(P<0.05),and the levels of inflammatory factors

关 键 词：面部外伤 瘢痕 点阵CO_(2)激光 富血小板血浆 炎症因子 

分 类 号：R622[医药卫生—整形外科]