纳米银抗菌水凝胶敷料联合rh-bFGF对踝关节开放性骨折术后创面恢复的 影响  

Effect of Nano-silver Antibacterial Hydrogel Dressing Combined with rh-bFGF on Wound Postoperative Recovery of Ankle Joint Open Fracture

作　　者：夏晓春 吕作刚 XIA Xiaochun;LYU Zuogang(Department of Orthopedics,Lujiang County Hospital of Traditional Chinese Medicine,Hefei 231500,Anhui,China;Department of Orthopedics,Chaohu Hospital Affiliated to Anhui Medical University,Hefei 238000,Anhui,China)

机构地区：[1]庐江县中医院骨科,安徽合肥231500 [2]安徽医科大学附属巢湖医院骨科,安徽合肥238000

出　　处：《中国美容医学》2024年第8期42-45,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究纳米银抗菌水凝胶敷料联合重组碱性成纤维细胞生长因子(Recombinant human basic fibroblast growth factor,rh-bFGF)对踝关节开放性骨折术后恢复的影响。方法:选取2020年1月-2022年12月于庐江县中医院接受创面修复的97例踝关节开放性骨折患者,按随机数字表法将其分为对照组(n=48例)和观察组(n=49例)。两组均行关节复位固定术,对照组术后予以凡士林敷料进行创面修复,观察组患者予以纳米银抗菌水凝胶敷料联合rh-bFGF进行创面修复。比较两组患者创面修复效果、关节疼痛肿胀情况、血清炎症因子水平[白介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)]及创面并发症发生情况。结果:观察组治疗总有效率高于对照组(P<0.05),创面血运恢复时间与愈合时间短于对照组(P<0.05);治疗8周后,观察组VAS评分、关节肿胀评分均低于对照组(P<0.05);治疗期间,观察组并发症发生率低于对照组(P<0.05)。结论:纳米银抗菌水凝胶敷料联合rh-bFGF利于踝关节开放性骨折患者术后创面及关节恢复,值得临床推荐。Objective To explore the effect of nano-silver antibacterial hydrogel dressing combined with recombinant human basic fibroblast growth factor(rh-bFGF)on on the postoperative recovery of ankle joint open fracture.Methods A total of 97 patients with open ankle fractures who underwent wound repair at Lujiang County Hospital of Traditional Chinese Medicine from January 2020 to December 2022 were divided into a control group(n=48)and an observation group(n=49)by random number table method.Patients in the control group were treated with vaseline dressing for wound repair,while those in the observation group were treated with nano-silver antibacterial hydrogel dressing combined with rh-bFGF for wound repair.The effect of wound repair,joint pain and swelling,serum inflammatory factors(interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factorα(TNF-α))and the incidence of wound complications were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05),and the wound blood flow recovery time and healing time were shorter than that of the control group(P<0.05).After 8 weeks of treatment,VAS score and joint swelling score of observation group were lower than those of control group(P<0.05).During treatment,the complication rate of observation group was lower than that of control group(P<0.05).Conclusion Nano silver antibacterial hydrogel dressing combined with rh-bFGF is beneficial to postoperative wound recovery and joint recovery in patients with ankle joint open fracture,which is worthy of clinical recommendation.

关 键 词：踝关节开放性骨折 创面修复 纳米银抗菌水凝胶敷料 重组碱性成纤维细胞生长因子 

分 类 号：R687.3[医药卫生—骨科学]