光动力联合A型肉毒毒素面部微滴注射治疗丘疹脓疱型玫瑰痤疮的临床疗效与安全性研究  

Clinical Efficacy and Safety of Photodynamic Therapy Combined with Microdroplet Technique with Botulinum Toxin Type A in the Treatment of Papular-pustular Rosacea

作　　者：樊娟丽 杨改娥 郭芳 李颖慧 FAN Juanli;YANG Gai'e;GUO Fang;LI Yinghui(Department of Dermatology,Yuncheng Central Hospital,Yuncheng 044000,Shanxi,China)

机构地区：[1]运城市中心医院皮肤科,山西运城044000

出　　处：《中国美容医学》2024年第8期107-111,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究光动力联合A型肉毒毒素微滴注射治疗丘疹脓疱型玫瑰痤疮的临床疗效与安全性。方法:回顾性选取2021年3月-2022年12月于笔者医院就诊的接受光动力和A型肉毒毒素多点微量注射治疗的丘疹脓疱型玫瑰痤疮患者,从中选择符合入组标准的患者共68例,采用抽签法将其分为对照组(n=30)和观察组(n=38),对照组患者接受光动力疗法,观察组光动力治疗结束1周后加用A型肉毒毒素微滴注射。治疗后4周观察比较两组患者丘疹脓疱、红斑、潮红、毛细血管扩张评分以及生活质量,分析两组临床症状评分变化、临床疗效和不良反应发生,并比较两组患者治疗后12周复发率情况。结果:两组患者治疗前丘疹脓疱、红斑、潮红、毛细血管扩张评分差异均无统计学意义(P>0.05)。治疗后4周两组丘疹、脓疱评分较治疗前明显降低,但组间比较差异均无统计学意义(P>0.05);治疗后4周观察组红斑、潮红评分均低于对照组(P<0.05)。观察组总有效率92.10%(34/38)高于对照组66.67%(20/30)(P<0.05)。两组12周后随访观察组复发率低于对照组,但两组间差异无统计学意义(P>0.05)。结论:光动力疗法对玫瑰痤疮丘疹脓疱有较好的疗效,联用A型肉毒毒素面部微滴注射能够更好减轻红斑和潮红症状,提高患者生活质量。Objective To explore the clinical efficacy and safety of photodynamic therapy combined with microdroplet technique using botulinum toxin type A in the treatment of papular-pustular rosacea.Methods Patients with papular-pustular rosacea who received photodynamic therapy and microdroplet technique with botulinum toxin type A at the author's hospital from March 2021 to December 2022 were selected.After inclusion and exclusion criteria were applied,68 patients who met the criteria were retrospectively enrolled and assigned into two groups according to a random lottery method.The control group(n=30)received photodynamic therapy,while the observation group(n=38)received the addition of microdroplet technique with botulinum toxin type A one week after photodynamic therapy.The scores of papules/pustules,centrofacial erythema,flushing,telangiectasia,and quality of life of the two groups were observed and compared at 4 weeks after the end of treatment.The changes in clinical symptom scores,clinical efficacy,and adverse reactions of the two groups were analyzed,and the recurrence rates at 12 weeks after treatment were compared.Results The scores of papules/pustules,centrofacial erythema,flushing,and telangiectasia showed no statistical difference between the two groups before treatment(P>0.05).At 4 weeks after treatment,a notable reduction in papules/pustules scores was observed in both groups compared to baseline data,but no statistical difference was found between the two groups in terms of the papules/pustules scores(P>0.05).However,the scores of centrofacial erythema and flushing in the observation group were significantly lower than those in the control group(P<0.05).The total efficacy rate was 92.10%(34/38)in the observation group,which was higher than 66.67%(20/30)in the control group,with a statistical difference(P<0.05).After 12 weeks of follow-up,the recurrence rate in the observation group was lower than that in the control group,but there was no significant difference between the two groups(P>0.05).Conclusion Ph

关 键 词：光动力疗法 A型肉毒毒素 微滴注射 丘疹 脓疱 玫瑰痤疮 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]