温阳化饮方联合布地奈德雾化吸入治疗儿童支气管哮喘的临床研究  

Clinical Study of Wenyang Huayin Recipe Combined with Aerosol Inhalation of Budesonide in the Treatment of Bronchial Asthma in Children

作　　者：余俏俏 陈万越 李宁 李君 YU Qiao-qiao;CHEN Wan-yue;LI Ning;LI Jun(Department of Pediatrics,Pingdingshan Hospital of Traditional Chinese Medicine,Pingdingshan 467000,China;School of Pediatrics,Henan University of traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]平顶山市中医医院儿科,平顶山467000 [2]河南中医药大学儿科医学院,郑州450000

出　　处：《中国合理用药探索》2024年第7期24-29,共6页Chinese Journal of Rational Drug Use

基　　金：河南省中医药科学研究专项课题(2022ZY2067)。

摘　　要：目的:探讨温阳化饮方联合布地奈德雾化吸入治疗儿童支气管哮喘的临床疗效及对患儿肺功能的影响。方法:选取2021年7月~2023年7月期间某院诊治的80例支气管哮喘患儿作为研究对象,采用随机数字表法分为对照组和观察组,每组40例。两组患儿均给予平喘、吸氧、化痰、抗感染等常规治疗,对照组患儿给予吸入用布地奈德混悬液雾化吸入,观察组患儿在对照组治疗基础上给予温阳化饮方治疗,两组均治疗7天。比较两组患儿中医证候积分、肺功能指标[用力肺活量(FVC)、呼气流量峰值(PEF)、第1秒用力呼气容积(FEV_(1))]、临床症状消失时间、临床疗效以及不良反应。结果:治疗后,两组患儿各项中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05);FEV_(1)、FVC、PEF均升高(P<0.05),且观察组高于对照组(P<0.05)。观察组患儿气急、咳嗽咳痰、哮鸣音、胸闷症状消失时间均短于对照组(P<0.05);观察组患儿临床治疗总有效率(97.50%)高于对照组(85.00%,P<0.05)。两组患儿不良反应总发生率比较无统计学差异(P>0.05)。结论:温阳化饮方联合布地奈德雾化吸入治疗儿童支气管哮喘临床疗效良好,可有效缓解患儿临床症状,降低中医证候积分,改善患儿肺功能,且不会增加不良反应的发生风险。Objective:To explore the clinical efficacy of Wenyang Huayin recipe combined with aerosol inhalation of budesonide in the treatment of children with bronchial asthma and its effect on children's pulmonary function.Methods:A total of 80 children with bronchial asthma treated in a hospital from July 2021 to July 2023 were selected and assigned to the control group and observation group by random number table method,with 40 cases in each group.Both groups of children were given conventional treatments such as relieving asthma,oxygen inhalation,expelling phlegm and anti-infection.The control group was treated with aerosol inhalation of budesonide suspension for inhalation,whereas the observation group was given Wenyang Huayin recipe in addition to the treatment given in the control group,and both groups were treated for 7 days.The traditional Chinese medicine(TCM)syndrome scores,pulmonary function indexes[forced vital capacity(FVC),peak expiratory flow(PEF),forced expiratory volume in one second(FEV_(1))],disappearance times of clinical symptoms,clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment,the TCM syndrome scores were decreased in both groups(P<0.05),and were lower in the observation group than those in the control group(P<0.05).FEV_(1),FVC and PEF were increased in both groups(P<0.05),and were higher in the observation group than those in the control group(P<0.05).The disappearance times of shortness of breath,cough and expectoration,wheeze and chest tightness in the observation group were shorter than those in the control group(P<0.05).The total response rate in the observation group(97.50%)was higher than that in the control group(85.00%,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Wenyang Huayin recipe combined with aerosol inhalation of budesonide has good clinical efficacy on bronchial asthma in children,which can effectively relieved clinical symptoms,reduced TCM

关 键 词：温阳化饮方 布地奈德 支气管哮喘发作期 寒饮停肺证 肺功能指标 

分 类 号：R725.6[医药卫生—儿科]