玛咖西洋参片缓解体力疲劳的动物实验观察  

Effect of Maca American Ginseng tablets on alleviating physical fatigue in animal exreriments

作　　者：徐冰[1] 袁鹏[1] 李江敏[1] 王燕[1] 高慧艳[1] 陈东方[1] 张聪恪[1] XU Bing;YUAN Peng;LI Jiangmin;WANG Yan;GAO Huiyan;CHEN Dongfang;ZHANG Congke(Henan Center for Disease Control and Prevention,Zhengzhou,Henan 450016,China)

机构地区：[1]河南省疾病预防控制中心,河南郑州450016

出　　处：《现代疾病预防控制》2024年第7期514-517,共4页MODERN DISEASE CONTROL AND PREVENTION

基　　金：河南省重点研发与推广专项(科技攻关)项目(232102231040);河南省医学科技攻关计划联合共建项目(LHGJ20220152)。

摘　　要：目的研究玛咖西洋参片缓解体力疲劳的作用。方法BALB/c小鼠分为4批,每批48只。每批小鼠随机分为溶剂对照组、低剂量组(0.35 g/kg)、中剂量组(0.70 g/kg)和高剂量组(2.10 g/kg)4组,每组12只。对照组给予蒸馏水,3个剂量组按剂量给予玛咖西洋参片。连续灌胃30 d后,分别测定负重游泳时间、肝糖原含量、血清尿素含量以及血乳酸水平。结果中剂量组和高剂量组小鼠负重游泳时间分别为(8.80±0.69)、(9.35±1.05)min,均高于溶剂对照组(P均<0.05);低、中、高3个剂量组肝糖原含量分别为(3101±305)、(3209±265)、(3503±398)mg/100 g肝组织,均高于溶剂对照组(P均<0.05);中剂量组和高剂量组小鼠运动时血清尿素含量分别为(12.03±0.95)、(11.53±0.86)mmol/L,均低于溶剂对照组(P均<0.05);中剂量组和高剂量组小鼠运动后血乳酸曲线下面积分别为(145.17±10.49)、(138.66±10.78),均低于溶剂对照组(P均<0.05)。结论玛咖西洋参片能够有效缓解体力疲劳,作用机制与其增加肝糖原贮备能力,减少氨基酸分解代谢产物,加快运动恢复期乳酸的清除代谢速度有关。Objective To evaluate the anti-fatigue effects of Maca American Ginseng tablets in an animal molde.Methods Four identical experiment were conducted.In each experiment,forty-eight BALB/c mice were randomly divided into four groups:a solvent control group and three experimental groups receiving low(0.35 g/kg),midium(0.70 g/kg),and high(2.10 g/kg)doses of Maca American Ginseng Tablets.The control group was given distilled water,while experimental groups were gavage administrated with the respective dosages for 30 consecutive days.Subsequently,the load-bearing swimming time,hepatic glycogen contents,serum urea contents,and blood lactate levels were measured.Results Mice in the medium and high-dose groups exhibited increased load-bearing swimming times of(8.80±0.69)min and(9.35±1.05)min,respectively,compared to the solvent control group(all P<0.05).Hepatic glycogen content was elevated in the low(3101±305 mg/100 g),medium(3209±265 mg/100 g),and high(3503±398 mg/100 g)dose groups significantly higher than those in the solvent control group(all P<0.05).Serum urea content was reduced in the medium(12.03±0.95 mmol/L)and high-dose(11.53±0.86 mmol/L)groups compared to those in the solvent control group(all P<0.05).Post-exercise blood lactate levels were lower in in the in medium(145.17±10.49)and high-dose(138.66±10.78)groups compared to the solvent control group(all P<0.05).Conclusions Maca American Ginseng tablets effectively alleviate physical fatigue,potentially through increased hepatic glycogen storage,t reduced amino acid metabolite levels,and accelerated lactate metabolic clearance during recovery.

关 键 词：玛咖粉 西洋参 抗疲劳 动物模型 小鼠 

分 类 号：R285[医药卫生—中药学]