肿瘤微环境中NLRP3炎症小体对乳腺癌转移的研究现状  

Research status on the role of NLRP3 inflammasome in tumor micro-environment on breast cancer metastasis

作　　者：华林晔 罗弘杉 林秀莲 林丽美 夏伯候 李亚梅 HUA Lin-ye;LUO Hong-shan;LIN Xiu-lian;LIN Li-mei;XIA Bo-Hou;LI Ya-mei(School of Pharmacy,Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province,Hunan University of Chinese Medicine,Changsha 410208,Hunan Province,China;Medical School,Hunan University of Chinese Medicine,Changsha 410208,Hunan Province,China)

机构地区：[1]湖南中医药大学,药学院湘产大宗药材品质评价湖南省重点实验室,湖南长沙410208 [2]湖南中医药大学,医学院,湖南长沙410208

出　　处：《中国临床药理学杂志》2024年第14期2148-2152,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家级大学生创新创业训练计划基金资助项目(202210541136);湖南省教育厅科研项目优秀青年基金资助项目(23B0383);湖南中医药大学校级基金资助项目(2020XJJJ011)。

摘　　要：NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎症小体在乳腺癌组织中的表达水平明显升高,高水平的NLRP3炎症小体与乳腺癌的转移密切相关。NLRP3炎症小体激活可诱导炎性因子释放至肿瘤微环境(TME)。炎性因子通过向癌细胞传递信号而重构TME促进肿瘤生长和侵袭,进而促进细胞发生上皮-间充质转化,赋予癌细胞获得向远处靶器官定植的能力,增加转移性病灶。本文针对乳腺癌TME下NLRP3炎症小体与乳腺癌转移的研究现状以及研究前景进行综述,以期能为研究乳腺癌转移机制和治疗方案提供新思路。The expression level of NOD-like receptors(NLRP3)inflammasome is significantly elevated in breast cancer tissues,and a high level of NLRP3 inflammasomes is closely associated with breast cancer metastasis.Activation of NLRP3 inflammasome can induce the release of inflammatory factors into the tumor microenvironment(TME).These inflammatory factors,by signaling to cancer cells,reshape the TME to promote tumor growth and invasion,ultimately facilitating the process of epithelial-mesenchymal transition.This equips cancer cells with the ability to establish distant metastases and increase the formation of metastatic lesions.This review addresses the current research status and prospects of NLRP3 inflammasomes in the breast cancer TME and their role in breast cancer metastasis.The goal is to provide new insights for the study of breast cancer metastasis mechanisms and treatment strategies.

关 键 词：乳腺癌 肿瘤转移 NOD样受体热蛋白结构域相关蛋白3炎症小体 肿瘤微环境 

分 类 号：R97[医药卫生—药品]