布地奈德联合肺表面活性物质气管内给药预防早产儿支气管肺发育不良的应用效果研究  

Study on the application effect of Budesonide combined with pulmonary surfactant intratracheal administration in the prevention of bronchepulmonary dysplasia in premature infants

作　　者：邬艳萍 易亮 许伟 WU Yanping;YI Liang;XU Wei(Department of Neonatology,Ping Xiang Maternity and Child Care,Jiangxi Province,Pingxiang337000,China)

机构地区：[1]江西省萍乡市妇幼保健院新生儿科,江西萍乡337000

出　　处：《中国当代医药》2024年第22期81-84,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202311753)。

摘　　要：目的探讨布地奈德联合肺表面活性物质(PS)气管内给药预防早产儿支气管肺发育不良(BPD)的应用效果。方法选取2022年1月至2023年8月萍乡市妇幼保健院新生儿科收治的40例BPD高危患儿作为研究对象,通过随机数字表法分为观察组与对照组,每组各20例。对照组单纯应用外源性PS治疗,观察组在对照组方法基础上加用布地奈德治疗。比较两组患儿的PS重复应用次数、鼻导管吸氧时间、有创通气时间、无创通气时间、呼吸机使用时间、氧疗总时间、BPD发生率、总住院时间、住院费用,以及各种并发症的发生率等。结果观察组的BPD总发生率低于对照组,差异有统计学意义(P<0.05)。观察组的PS重复应用次数少于常规组,有创通气时间、无创通气时间、呼吸机使用时间、氧疗总时间均短于对照组,差异有统计学意义(P<0.05);两组患儿的鼻导管吸氧时间比较,差异无统计学意义(P>0.05)。观察组的住院费用低于对照组,差异有统计学意义(P<0.05);两组患儿的总住院时间比较,差异无统计学意义(P>0.05)。两组患儿的并发症发生率比较,差异无统计学意义(P>0.05)。结论与单纯使用PS相比,布地奈德联合PS治疗BPD高危早产儿可以减少PS的重复使用次数,减少呼吸支持时间,降低BPD发生率及严重程度,且未增加糖皮质激素相关并发症的发生率,值得临床推广使用。Objective To explore the application effect of Budesonide combined with pulmonary surfactant(PS)intratracheal administration in the prevention of bronchepulmonary dysplasia(BPD)in premature infants.Methods A total of 40 high-risk infants with BPD admitted to the Department of Neonatology,Ping Xiang Maternity and Child Care from January 2022 to August 2023 were selected as the research objects.They were divided into observation group and control group by random number table method,with 20 cases in each group.The control group was treated with exogenous PS alone,and the observation group was treated with Budesonide on the basis of the control group.The number of PS repeated application,nasal catheter oxygen inhalation time,invasive ventilation time,non-invasive ventilation time,ventilator use time,total oxygen therapy time,incidence and severity of BPD,total hospitalization time,hospitalization cost,and incidence of various complications were compared between the two groups.Results The total incidence of BPD in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The repeated application times of PS in the observation group was less than that in the conventional group,and the invasive ventilation time,non-invasive ventilation time,ventilator use time and total oxygen therapy time were shorter than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the time of oxygen inhalation through nasal catheter between the two groups(P>0.05).The hospitalization cost of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total length of hospital stay between the two groups(P>0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Compared with the use of PS alone,the combination of Budesonide and PS in the treatment of high-ris

关 键 词：布地奈德 肺表面活性物质 气管内给药 预防 早产儿 支气管肺发育不良 

分 类 号：R722.6[医药卫生—儿科]