Box-Behnken响应面法优化荆芥穗挥发油β-环糊精包合物的高速剪切包合工艺  

Optimization of high-speed shear inclusion process on Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex by Box-Behnken response surface method

作　　者：郝晓卓 姜国志 李军山 HAO Xiaozhuo;JIANG Guozhi;LI Junshan(Shineway Pharmaceutical Group Co.,Ltd.,Shijiazhuang 051430,China;Yunnan Provincial Key Laboratory of Formula Granules,Chuxiong 675000,China;Yunnan Shineway Sprui Co.,Ltd.,Chuxiong 675000,China)

机构地区：[1]神威药业集团有限公司,河北石家庄051430 [2]云南省配方颗粒重点实验室,云南楚雄675000 [3]云南神威施普瑞药业有限公司,云南楚雄675000

出　　处：《现代药物与临床》2024年第6期1454-1459,共6页Drugs & Clinic

基　　金：云南省重大科技专项计划(202102AA310027);云南省科技人才与平台计划(202105AG070014);石家庄市产业技术研究院建设任务(228790779A)。

摘　　要：目的 优化荆芥穗挥发油β-环糊精包合物的高速剪切包合工艺。方法 在单因素考察的基础上,以包合物收率、胡薄荷酮包合率的综合评分为评价指标,以β-环糊精与挥发油倍量比、剪切转速和剪切包合时间为考察因素,采用Box-Behnken响应面法进行包合工艺优化,通过Design-Expert 13软件分析各因素的交互作用优选最佳工艺条件。结果 采用高速剪切法制备荆芥穗挥发油β-环糊精包合物的最佳工艺参数为β-环糊精与挥发油倍量比为8∶1,β-环糊精与纯化水倍量比1∶8,剪切包合时间40 min,剪切转速为7 700 r/min。结论 优化后的工艺包合率和收率较高,工艺合理可行,对后续产品的研究和生产具有一定指导作用。Objective To optimize the high-speed shear inclusion process on Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex.MethodsOn the basis of single factor test,the inclusion process was optimized by Box-Behnken response surface method with the comprehensive score of inclusion complex yield and pulegone inclusion rate as the evaluation index,and mass ratio ofβ-cyclodextrin to volatile oil,shear speed,and shear time as the investigation factors.The optimum process conditions were selected by analyzing the interaction of various factors by Design-Expert 13 software.Results The optimum process parameters of preparing Schizonepetae Spica volatile oil-β-cyclodextrin inclusion complex by high-speed shearing method were as following:the ratio ofβ-cyclodextrin to volatile oil was 8:1,the mass ratio ofβ-cyclodextrin to purified water was 1:8,the shearing inclusion time was 40 min,and the shearing speed was 7700 r/min.Conclusion The optimized process has high inclusion rate and inclusion yield,and the process is reasonable and feasible,which has a certain guiding role for the research and production of subsequent products.

关 键 词：荆芥穗挥发油β-环糊精包合物 高速剪切 包合工艺 收率 包合率 Box-Behnken响应面法 

分 类 号：R284.2[医药卫生—中药学]