复方木尼孜其颗粒联合依美斯汀治疗慢性荨麻疹的临床研究  

Clinical study on Compound Muni Ziqi Granules combined with emedastine in treatment of chronic urticaria

作　　者：朱丽英[1] 谷守娜 于文成[1] ZHU Liying;GU Shouna;YU Wencheng(Department of Dermatology,Linxi Hospital of Kailuan General Hospital,Tangshan 063103,China)

机构地区：[1]开滦总医院林西医院皮肤科,河北唐山063103

出　　处：《现代药物与临床》2024年第6期1582-1586,共5页Drugs & Clinic

基　　金：河北省医学科学研究重点课题计划项目(20211809)。

摘　　要：目的 探讨复方木尼孜其颗粒联合依美斯汀治疗慢性荨麻疹的临床疗效。方法 选取2021年6月—2023年9月开滦总医院林西医院收治的慢性荨麻疹患者148例,依据用药情况将患者分为对照组(74例)和治疗组(74例)。对照组患者口服富马酸依美斯汀缓释胶囊,1粒/次,2次/d。在对照组的基础上,治疗组口服复方木尼孜其颗粒,6 g/次,3次/d。两组用药15 d。观察两组患者临床疗效,比较治疗前后两组患者症状缓解时间,荨麻疹活动度评分(UAS)和慢性荨麻疹生活质量问卷评分量表(GU-Q2oL)评分,血清白细胞介素-33(IL-33)、血清淀粉样蛋白(SAA)、D-二聚体(D-D)和干扰素-γ(IFN-γ)水平。结果 治疗后,治疗组临床总有效率为95.94%,明显高于对照组总有效率(86.49%,P<0.05)。治疗后,治疗组患者症状缓解时间均明显早于对照组(P<0.05)。治疗后,两组患者UAS评分和GU-Q2o L评分明显低于治疗前(P<0.05),且治疗组评分均低于对照组(P<0.05)。治疗后,两组患者血清IL-33、SAA和D-D水平明显降低,而INF-γ水平则明显升高(P<0.05),且治疗组明显好于对照组(P<0.05)。结论 复方木尼孜其颗粒联合依美斯汀治疗慢性荨麻疹能有效改善临床症状,显著提升荨疫能力及生活质量,减弱机体内炎性反应。Objective To explore the clinical effect of Compound Muni Ziqi Granules combined with emedastine in treatment of chronic urticaria.Methods Patients(148 cases)with chronic urticaria in Linxi Hospital of Kailuan General Hospital from June 2021 to September 2023 were divided into control(74 cases)and treatment(74 cases)group based on different treatments.Patients in the control group were po administered with Emedastine Difumarate Sustained-release Capsules,1 grains/time,twice daily.Patients in the treatment group were po administered with Compound Muni Ziqi Granules on the basis of the control group,6 g/time,three times daily.Patients in two groups were treated for 15 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores ofUAS and GU-Q2oL,the levels of serum IL-33,SAA,D-D and INF-in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 95.94%,which was significantly higher than that of the control group(86.49%,P<0.05).After treatment,the time of symptom relief in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the scores of UAS and GU-Q2oL in two groups were significantly lower(P<0.05),and the scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of serum IL-33,SAA and D-D in two groups were significantly decreased,while the level of INF-was significantly increased(P<0.05),and which in the treatment group was significantly better than that in the control group(P<0.05).Conclusion Compound Muni Ziqi Granules combined with emedastine in treatment of chronic urticaria can effectively improve the clinical symptoms,significantly improve the ability and quality of life of urticaria,and weaken the inflammatory reaction.

关 键 词：复方木尼孜其颗粒 富马酸依美斯汀缓释胶囊 慢性荨麻疹 荨麻疹活动度评分 血清淀粉样蛋白 D-二聚体 

分 类 号：R986[医药卫生—药品]