雷公藤甲素治疗胰腺癌的研究进展  

Research progress oftriptolide in treatment of pancreatic cancer

作　　者：赵文文 郭晓琦 朱缓缓 曾华辉[3] 武香香[3] ZHAO Wenwen;GUO Xiaoqi;ZHU Huanhuan;ZENG Huahui;WU Xiangxiang(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南中医药大学医学院,河南郑州450046 [3]河南中医药大学中医药科学院,河南郑州450046

出　　处：《现代药物与临床》2024年第6期1631-1636,共6页Drugs & Clinic

基　　金：河南省自然科学基金优秀青年基金项目(212300410057);河南省科技研发计划联合基金项目(222301420060)。

摘　　要：胰腺癌是一种消化道常见恶性肿瘤之一,预后差,诊断期较晚。雷公藤甲素是雷公藤中有效成分之一,具有显著的药理活性。雷公藤甲素可通过抑制细胞周期和增殖、诱导细胞凋亡、抑制细胞迁移和侵袭、调节肿瘤血管生成、协同其他药物抗耐药、抑制热休克蛋白相关基因、诱导自噬等多种途径治疗胰腺癌。总结了雷公藤甲素治疗胰腺癌的药理作用及其作用机制的研究进展,为雷公藤甲素成为胰腺癌治疗的候选药物提供依据。Pancreatic cancer is one of the common malignant tumors of digestive tract,with poor prognosis and late diagnosis.Triptolide is one of the effective ingredients in Tripterygii Radix et Rhizoma,with significant pharmacological activity.Triptolide can treat pancreatic cancer by inhibiting cell cycle and proliferation,inducing apoptosis,inhibiting cell migration and invasion,regulating tumor angiogenesis,cooperating with other drugs to resist drug resistance,inhibiting heat shock protein related genes,inducing autophagy.This article summarized the pharmacological action and mechanism of triptolide in treatment of pancreatic cancer,providing a basis for triptolide to become a candidate drug for the treatment of pancreatic cancer.

关 键 词：雷公藤甲素 胰腺癌 细胞凋亡 细胞迁移 细胞侵袭 肿瘤血管生成 抗耐药 热休克蛋白 自噬 

分 类 号：R965[医药卫生—药理学]