疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期的Meta分析及药物经济学评价  

Meta-analysis and Pharmacoeconomic Evaluation of Shufeng Jiedu(疏风解毒)Capsules in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：任慧君 许晶晶 罗娇 徐敏[1] 杨艳[1] 付昆[1] REN Huijun;XU Jingjing;LUO Jiao;XU Min;YANG Yan;FU Kun(Department of Pharmacy,The Third People’s Hospital of Chengdu,Chengdu 610014)

机构地区：[1]成都市第三人民医院药学部,成都610014

出　　处：《中药药理与临床》2024年第6期83-88,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金资助项目(编号:81703781);四川省中医药管理局中医药科研专项课题(编号:2020JC0009);成都市第三人民医院院内科研项目资助(编号:CSY-YN-01-2023-063)。

摘　　要：目的:系统评价疏风解毒胶囊(SFJDC)联合西医常规与西医常规治疗慢性阻塞性肺疾病加重期(AECOPD)的临床疗效和经济性。方法:检索中国学术期刊全文数据库(CNKI)、万方数据知识服务平台、维普中文科技期刊数据库(VIP)、PubMed、EMbase数据库,检索日期截至2023年6月,按照纳入与排除标准筛选文献,提取数据,通过Meta分析与成本效果分析法对2种方案治疗慢性阻塞性肺疾病临床疗效和经济性进行评价。结果:临床疗效:疏风解毒胶囊联合方案与常规方案治疗AECOPD总有效率分别为88.43%和73.69%,且安全性无显著差异。经济性:疏风解毒胶囊联合方案与常规方案治疗AECOPD住院与非住院患者总有效率的成本效果分析发现,疏风解毒胶囊联合方案组成本效果比(CER)小于常规方案组,表明疏风解毒联合方案更具有经济性。敏感性分析结果较为稳健。结论:疏风解毒胶囊联合常规方案在治疗AECOPD的临床疗效和经济性方面,都优于常规治疗方案,为优势方案。Objective:To systematically evaluate the clinical efficacy and cost-effectiveness of Shufeng Jiedu(疏风解毒)Capsules(SFJDC)combined with conventional western medicine versus conventional western medicine alone in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,PubMed,and EMbase were searched from database inception to June 2023.Following inclusion and exclusion criteria,literature was screened,and data were extracted.Meta-analysis and cost-effectiveness analysis were conducted to evaluate the clinical efficacy and cost-effectiveness of the two treatment regimens for AECOPD.Results:Clinical efficacy:The total effective rates of SFJDC combined with conventional therapy and conventional therapy alone in treating AECOPD were 88.43%and 73.69%,respectively,with no significant difference in safety.Cost-effectiveness:Cost-effectiveness analysis of the total effective rate for hospitalized and non-hospitalized AECOPD patients treated with SFJDC combined therapy versus conventional therapy revealed that the cost-effectiveness ratio(CER)of the SFJDC combined therapy group was lower than that of the conventional therapy group,indicating that the SFJDC combined therapy was more cost-effective.Sensitivity analysis results were robust.Conclusion:SFJDC combined with conventional therapy is superior to conventional therapy alone in terms of both clinical efficacy and cost-effectiveness in the treatment of AECOPD,making it an advantageous treatment regimen.

关 键 词：疏风解毒胶囊 META分析 成本效果分析 慢性阻塞性肺病急性加重期 

分 类 号：R259[医药卫生—中西医结合]