白桦脂酸及其衍生物的抗肿瘤作用和机理研究进展  

Progress in Anti-Tumor Effects and Mechanisms of Betulinic Acid and Its Derivatives

作　　者：赵欢 林雪燕 牛圆圆 陈雨慧 余悦[2] 李东晓[2] 徐超群[2] ZHAO Huan;LIN Xueyan;NIU Yuanyuan;CHEN Yuhui;YU Yue;LI Dongxiao;XU Chaoqun(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 610041;Sichuan Provincial Key Laboratory of Chinese Materia Medica Quality and Innovative Chinese Medicine Research/Sichuan-Chongqing Joint Key Laboratory for the Creation and Quality Evaluation of New Chinese Medicines,Sichuan Academy of Chinese Medicine Sciences,Chengdu 610041)

机构地区：[1]成都中医药大学药学院,成都610041 [2]四川省中医药科学院,中药材品质及创新中药研究四川省重点实验室/中药新药创制与质量评价川渝共建重点实验室,成都610041

出　　处：《中药药理与临床》2024年第6期109-115,共7页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家重大新药创制项目(编号:2018ZX09731013);四川省中医药人才培养项目;四川省中药药理学重点学科建设项目(编号:2020ZDXK01);四川省科技厅省级科研院所基本科研业务专项项目(编号:2022JDKY0013)。

摘　　要：白桦脂酸(Betulinic acid,BA)为羽扇豆烷型五环三萜类化合物,在马甲子、杜仲和酸枣仁等多种中药中均含量较高。既有研究显示白桦脂酸具有抗肿瘤、抗炎、抗HIV、抗疟疾、抗菌和抗氧化等多种生物活性,尤其是在抗肿瘤方面,因其低毒、高效的特点而受到广泛重视,相关机理研究也较多,包括线粒体途径、Sp转录因子途径以及自噬等,但总体并不清晰。本文对白桦脂酸抗肿瘤作用机制进行综述,分瘤种厘清现有发现,分析研究热点,以期为白桦脂酸和以白桦脂酸及其类似物为主要药效成分的抗肿瘤药物研究提供参考。Betulinic acid(BA)is a lupinane-type pentacyclic triterpenoid with high content in a variety of Chinese medicinal materials,such as Majiazi(马甲子),Duzhong(杜仲),and Suanzaoren(酸枣仁).Studies have demonstrated that BA has anti-tumor,anti-inflammatory,anti-HIV,anti-malarial,antimicrobial,and antioxidant activities.It has attracted much attention in the treatment of tumors because of the low toxicity and high efficiency.Accordingly,extensive studies have been conducted about the related mechanisms,including the mitochondrial pathway,the Sp transcription factor pathway,and autophagy,while the overall picture remains unclear.In this paper,we reviewed the anti-tumor mechanism of BA,clarified the existing findings regarding different tumors,and analyzed the research hotspots,aiming to provide references for the research on BA and anti-tumor drugs with BA and its analogs as the main pharmacodynamic components.

关 键 词：白桦脂酸 抗肿瘤 五环三萜 线粒体 细胞周期 自噬 凋亡 

分 类 号：R285[医药卫生—中药学]