Compartmentalization of the inflammatory response during bacterial sepsis and severe COVID-19  

作　　者：Jean-Marc Cavaillon Benjamin G.Chousterman Tomasz Skirecki 

机构地区：[1]Institut Pasteur,Paris,France [2]Department of Anesthesia and Critical Care,Lariboisière University Hospital,DMU Parabol,APHP Nord,Paris,France [3]Inserm U942,University of Paris,Paris,France [4]Department of Translational Immunology and Experimental Intensive Care,Centre of Postgraduate Medical Education,Warsaw,Poland

出　　处：《Journal of Intensive Medicine》2024年第3期326-340,共15页重症医学（英文）

摘　　要：Acute infections cause local and systemic disorders which can lead in the most severe forms to multi-organ failure and eventually to death. The host response to infection encompasses a large spectrum of reactions with a concomitant activation of the so-called inflammatory response aimed at fighting the infectious agent and removing damaged tissues or cells, and the anti-inflammatory response aimed at controlling inflammation and initiating the healing process. Fine-tuning at the local and systemic levels is key to preventing local and remote injury due to immune system activation. Thus, during bacterial sepsis and Coronavirus disease 2019 (COVID-19), concomitant systemic and compartmentalized pro-inflammatory and compensatory anti-inflammatory responses are occurring. Immune cells (e.g., macrophages, neutrophils, natural killer cells, and T-lymphocytes), as well as endothelial cells, differ from one compartment to another and contribute to specific organ responses to sterile and microbial insult. Furthermore, tissue-specific microbiota influences the local and systemic response. A better understanding of the tissue-specific immune status, the organ immunity crosstalk, and the role of specific mediators during sepsis and COVID-19 can foster the development of more accurate biomarkers for better diagnosis and prognosis and help to define appropriate host-targeted treatments and vaccines in the context of precision medicine.

关 键 词：Acute respiratory distress syndrome Bone marrow CYTOKINES Lungs MUCOSA Vaccines 

分 类 号：R563.1[医药卫生—呼吸系统]